Id |
Subject |
Object |
Predicate |
Lexical cue |
T578 |
0-4 |
Sentence |
denotes |
3.6. |
T579 |
5-18 |
Sentence |
denotes |
South America |
T580 |
20-26 |
Sentence |
denotes |
3.6.1. |
T581 |
27-36 |
Sentence |
denotes |
Argentina |
T582 |
37-211 |
Sentence |
denotes |
After influenza virus outbreak hit a swine farm in Buenos Aires in November 2008, one of the five dead swine were diagnosed with viral pneumonia through immunohistochemistry. |
T583 |
212-380 |
Sentence |
denotes |
A full genome of H3N2 virus sharing 96–98% nucleotide sequence identity with H3N2 viruses reported in North America during 2000–2003 was recovered from the swine [314]. |
T584 |
381-598 |
Sentence |
denotes |
An H1N1 virus was reported from a swine after a swine farm manager along with his spouse experienced influenza-like symptoms few days before the outbreak erupted in the swine at a Buenos Aires based farm in June 2009. |
T585 |
599-673 |
Sentence |
denotes |
The influenza disease symptoms lasted for about a week in nursery piglets. |
T586 |
674-843 |
Sentence |
denotes |
Immunohistochemistry identified necrotizing bronchiolitis in four of the swine post-mortem samples while one sample had severe inflammation in the bronchiolar epithelia. |
T587 |
844-1045 |
Sentence |
denotes |
The serological investigation detected IAV antibodies in most of the sera samples collected after 15 days of onset of clinical symptoms however the active infection was reduced to only six swine [315]. |
T588 |
1046-1345 |
Sentence |
denotes |
The third investigation carried out histopathology which identified lung lesions compatible to the influenza virus infection in nine swine necropsy samples at a Buenos Aires based swine farm in October 2009 and later in eight swine necropsy samples originated from a Santa Fe based farm in May 2010. |
T589 |
1346-1574 |
Sentence |
denotes |
The swine at Buenos Aires farm were found infected with H1N1 virus while the swine at the Santa Fe farm retrieved one H1N2 and three human-like reassortant A(H1N1)pdm09 virus isolates which had triple reassortant internal genes. |
T590 |
1575-1674 |
Sentence |
denotes |
This was the first report of human-like reassortant A(H1N1)pdm09 virus in swine in Argentina [316]. |
T591 |
1675-1914 |
Sentence |
denotes |
Later two more investigations using histopathology, immunohistochemistry, serology, and molecular analyses reported H1N2, H3N2, and reassortant H3N2 viruses with A(H1N1)pdm09 internal genes in swine in Argentina during 2011–2012 [317,318]. |
T592 |
1916-1922 |
Sentence |
denotes |
3.6.2. |
T593 |
1923-1929 |
Sentence |
denotes |
Brazil |
T594 |
1930-2173 |
Sentence |
denotes |
Several H1N1, H1N2, H3N2, human-like H1N1, and A(H1N1)pdm09 viruses have been identified in Brazilian swine from the Minas Gerais, Parana, Rio Grande do Sul and Sao Paulo provinces in Brazil during and after 2009 [319,320,321,322,323,324,325]. |
T595 |
2174-2304 |
Sentence |
denotes |
A technician who visited a Minas Gerais swine farm experiencing influenza outbreak developed similar respiratory disease symptoms. |
T596 |
2305-2558 |
Sentence |
denotes |
The nasal swab sample was obtained from the technician, as a result, one A(H1N1)pdm09 virus was isolated which was closely related to the A(H1N1)pdm09 viruses reported from the swine herd in the Minas Gerais which was recently visited by the technician. |
T597 |
2559-2686 |
Sentence |
denotes |
Hence it was concluded that a zoonotic transmission from swine to the technician occurred at the Minas Gerais swine farm [326]. |
T598 |
2687-2909 |
Sentence |
denotes |
An immunohistochemical investigation demonstrated microscopic lesions suggesting broncho-interstitial pneumonia in the lung tissues of four severely sick piglets at a swine farm located in Parana province in February 2011. |
T599 |
2910-2966 |
Sentence |
denotes |
The A(H1N1)pdm09 viruses were isolated from two piglets. |
T600 |
2967-3037 |
Sentence |
denotes |
Additionally, a novel reassortant H1N2 virus was also recovered [327]. |
T601 |
3038-3139 |
Sentence |
denotes |
One more investigation identified that A(H1N1)pdm09 virus was the most prevalent IAV subtype in sows. |
T602 |
3140-3259 |
Sentence |
denotes |
The co-infections of sows with A(H1N1)pdm09, H1N2, or H3N2 subtypes were also documented in Rio Grande do Sul province. |
T603 |
3260-3406 |
Sentence |
denotes |
These findings were noteworthy because the coinfections may trigger reassortments and thus may facilitate emergence of novel strains of IAV [328]. |
T604 |
3407-3520 |
Sentence |
denotes |
Later two more H1N2 viruses were isolated and characterized from swine in Rio Grande do Sul province during 2013. |
T605 |
3521-3725 |
Sentence |
denotes |
The sequences of both the isolates had high nucleotide similarity to each other in different genome segments in the range of 98.9% to 100% which suggested a common source of origin of both isolates [329]. |
T606 |
3727-3733 |
Sentence |
denotes |
3.6.3. |
T607 |
3734-3742 |
Sentence |
denotes |
Colombia |
T608 |
3743-3837 |
Sentence |
denotes |
The A(H1N1)pdm09 virus was identified in seven swine farms in Colombia during 2008–2009 [330]. |
T609 |
3839-3845 |
Sentence |
denotes |
3.6.4. |
T610 |
3846-3850 |
Sentence |
denotes |
Peru |
T611 |
3851-3960 |
Sentence |
denotes |
The A(H1N1)pdm09 virus antibodies were detected in 110 backyard swine in Peru during March 2009–October 2011. |
T612 |
3961-4169 |
Sentence |
denotes |
Total four A(H1N1)pdm09 virus isolates were retrieved and sequenced which determined that there were at least two separate events of A(H1N1)pdm09 virus transmission from human to backyard swine in Peru [331]. |
T613 |
4171-4177 |
Sentence |
denotes |
3.6.5. |
T614 |
4178-4183 |
Sentence |
denotes |
Chile |
T615 |
4184-4282 |
Sentence |
denotes |
The backyard productive systems (BPS) for raising swine, cattle, and poultry are popular in Chile. |
T616 |
4283-4559 |
Sentence |
denotes |
A molecular investigation reported a negative active IAV infection across 113 BPS units within ten counties in Chile during 2012–2014 but the serological investigation detected IAV antibodies in swine at two BPS units which suggested a past exposure of swine to the IAV [332]. |
T617 |
4560-4723 |
Sentence |
denotes |
Interestingly, the HA gene sequence of an H12 virus was obtained from a domestic Muscovy duck at one of the BPS which appeared to have originated from a wild bird. |
T618 |
4724-4812 |
Sentence |
denotes |
This suggested a spillover of the IAV from wild reservoir to the domestic poultry [332]. |
T619 |
4813-4968 |
Sentence |
denotes |
Another study reported the prevalence of H1N2 virus in swine reared at 40 different BPS having poultry and swine in El Yali wetland during 2013–2014 [333]. |
T620 |
4969-5122 |
Sentence |
denotes |
One more study identified four swine sera samples (4/64; 6.3%) that were found positive for IAV antibodies collected from different BPS in Central Chile. |
T621 |
5123-5226 |
Sentence |
denotes |
One pool of swine nasal swab samples (1/39; 2.6%) was also detected IAV positive with real-time RT-PCR. |
T622 |
5227-5362 |
Sentence |
denotes |
Interestingly, 7.9% chicken, 4.3% ducks and 11.1% geese samples collected from 329 BPS in Central Chile also had active IAV infections. |
T623 |
5363-5485 |
Sentence |
denotes |
The breeding practice of poultry and swine in the BPS was determined to be a major risk factor for IAV transmission [334]. |
T624 |
5486-5683 |
Sentence |
denotes |
Briefly, the IAV strains of H1N1, H1N2, H3N2, and A(H1N1)pdm09 viruses have been reported from the swine in Argentina and Brazil while A(H1N1)pdm09 virus was reported in swine in Colombia and Peru. |
T625 |
5684-5747 |
Sentence |
denotes |
Swine in Chile were found infected with H1N2 virus (Figure 4F). |
T626 |
5748-5875 |
Sentence |
denotes |
In summary, total 281 research articles were identified which reported several influenza viruses in swine populations globally. |
T627 |
5876-6056 |
Sentence |
denotes |
The highest number of studies were reported from Asia (n = 107), followed by North America (n = 76), Europe (n = 55), South America (n = 21), Africa (n = 18) and Australia (n = 4). |
T628 |
6057-6188 |
Sentence |
denotes |
The highest number of reports per country were documented in United States (n = 40) followed by China (n = 39) and Canada (n = 24). |
T629 |
6189-6275 |
Sentence |
denotes |
Until February 2020, influenza viruses have been reported from 53 countries worldwide. |
T630 |
6276-6411 |
Sentence |
denotes |
Four subtypes of IAV including H1N1, H1N2, H3N2, and A(H1N1)pdm09 viruses were most frequently detected in swine populations (Table 1). |
T631 |
6412-6709 |
Sentence |
denotes |
Most of the large-scale studies used serological investigations including ELISA, hemagglutinin inhibition (HI), neuraminidase inhibition (NI), virus neutralization (VN), or microneutralization (MN) assays for the determination of the seroprevalence and subtyping of the influenza viruses in swine. |
T632 |
6710-6796 |
Sentence |
denotes |
Several investigations used virus isolation for the confirmation and subtyping of IAV. |
T633 |
6797-6944 |
Sentence |
denotes |
Most of the virological investigations used one-step real-time RT-PCR and/or reverse-transcription PCR for influenza virus detection and subtyping. |
T634 |
6945-7143 |
Sentence |
denotes |
Sanger sequencing or next-generation sequencing using MiSeq or Ion Torrent sequencing successfully generated the influenza virus sequences from the swine samples for epidemiological interpretations. |
T635 |
7144-7344 |
Sentence |
denotes |
Histological examinations including immunohistochemistry or immunofluorescence were used to examine the swine lung or other internal organ tissue samples for the influenza virus diagnostics (Table 2). |