Id |
Subject |
Object |
Predicate |
Lexical cue |
T434 |
0-6 |
Sentence |
denotes |
3.5.1. |
T435 |
7-13 |
Sentence |
denotes |
Canada |
T436 |
14-134 |
Sentence |
denotes |
Shortly after a respiratory disease outbreak in swine in Manitoba, an autopsy was done on a dead swine on March 1, 1967. |
T437 |
135-298 |
Sentence |
denotes |
The histopathology confirmed the bronchitis in the deceased swine and a strain of IAV designated as “S/Manitoba/647/67” was characterized using IAV antisera [234]. |
T438 |
299-442 |
Sentence |
denotes |
The first report of H1N1 virus in Canadian swine appeared in Quebec during 1980s–1990s when five genotypes of H1N1 virus were identified [235]. |
T439 |
443-564 |
Sentence |
denotes |
Since then several studies have reported H1N1, H1N2 and H3N2 viruses in Canadian swine [236,237,238,239,240,241,242,243]. |
T440 |
565-747 |
Sentence |
denotes |
Another study reported nine isolates of swine influenza viruses with an antigenic variant from the sick swine having proliferative pneumonia in Quebec, Canada during 1990–1991 [244]. |
T441 |
748-909 |
Sentence |
denotes |
In a retrospective diagnosis, only one formalin-fixed paraffin embedded swine lung tissue collected during 1991 was found IAV positive with immunohistochemistry. |
T442 |
910-1041 |
Sentence |
denotes |
This investigation suggested that immunohistochemistry can be useful in retrospective diagnosis of the swine influenza virus [245]. |
T443 |
1042-1222 |
Sentence |
denotes |
The broncho-intestinal pneumonia in lung tissues of dead swine was reported on a swine farm which exhibited disease symptoms including coughing, weight loss, and labored breathing. |
T444 |
1223-1428 |
Sentence |
denotes |
Interestingly, before the onset of the disease symptoms, this farm conducted a routine serological surveillance of influenza virus which identified H1N1 virus in only one of the twelve swine samples [246]. |
T445 |
1429-1551 |
Sentence |
denotes |
Following this surveillance, a three-month old swine from the same farm was found positive for avian influenza virus H4N6. |
T446 |
1552-1612 |
Sentence |
denotes |
The complete genome of this H4N6 virus was reported in 1999. |
T447 |
1613-1683 |
Sentence |
denotes |
This was the first ever report of an avian-origin H4N6 virus in swine. |
T448 |
1684-1927 |
Sentence |
denotes |
The proximity of the swine farm to a natural lake where several wild bird species including waterfowls which were reported to visit frequently might be the reason behind the introduction of this avian influenza virus strain to the swine [246]. |
T449 |
1928-2084 |
Sentence |
denotes |
Later three avian-origin H3N3 influenza virus isolates were recovered from swine in eastern Ontario exhibiting weight loss and coughing during October 2001. |
T450 |
2085-2193 |
Sentence |
denotes |
On a nearby farm located approximately 30 kms away, another H3N3 virus isolate was recovered from the swine. |
T451 |
2194-2262 |
Sentence |
denotes |
There was no recorded movement of the swine between these two farms. |
T452 |
2263-2366 |
Sentence |
denotes |
Since these were avian-origin H3N3 viruses hence the role of birds in transmission cannot be ruled out. |
T453 |
2367-2516 |
Sentence |
denotes |
Later, on a third farm, where an influenza like disease had been affecting mainly the nursery piglets, an H1N1 virus was recovered in May 2002 [247]. |
T454 |
2517-2731 |
Sentence |
denotes |
Reassortant H1N1 and H1N2 viruses were detected in swine nasal swab or lung tissue samples obtained from three-week old piglets and sows exhibiting typical influenza-like symptoms in Ontario during 2003–2004 [248]. |
T455 |
2732-2902 |
Sentence |
denotes |
First triple-reassortant (avian/classical swine/human triple-reassortant) H3N2 viruses from four swine and one human nasal samples were identified in Ontario during 2005. |
T456 |
2903-3106 |
Sentence |
denotes |
The phylogenetic analysis determined that all the virus sequences were 100% identical to each other which apparently emerged from triple-reassortant H3N2 viruses reported in US based swine in 1988 [249]. |
T457 |
3107-3266 |
Sentence |
denotes |
One more report of triple-reassortant H3N2 (trH3N2) viruses appeared on the swine farms located in Saint-Hyacinthe, Assomption and Saint-Foy during early 2009. |
T458 |
3267-3414 |
Sentence |
denotes |
The trH3N2 viruses identified in this study were determined to be closely related to North American/Canadian trH3N2 viruses reported earlier [250]. |
T459 |
3415-3618 |
Sentence |
denotes |
Later A(H1N1)pdm09 and H1N1 viruses having internal genes of triple reassortant H3N2 virus were reported in swine in four provinces including Manitoba, Alberta, Saskatchewan and Quebec during 2009 [251]. |
T460 |
3619-3768 |
Sentence |
denotes |
The first evidence of A(H1N1)pdm09 virus in Canadian swine appeared in 2009 after the human workers at a swine farm developed influenza-like illness. |
T461 |
3769-3881 |
Sentence |
denotes |
The investigation identified that two farm workers along with 56 swine were positive for the A(H1N1)pdm09 virus. |
T462 |
3882-3957 |
Sentence |
denotes |
Transmission of A(H1N1)pdm09 virus from human to swine was suggested [252]. |
T463 |
3958-4095 |
Sentence |
denotes |
The same year 17 more swine were detected with A(H1N1)pdm09 virus after a respiratory disease outbreak hit the Alberta swine farms [253]. |
T464 |
4096-4257 |
Sentence |
denotes |
A reverse zoonotic transmission of A(H1N1)pdm09 virus to swine from a human subject who visited Mexico and returned to the swine farm was reported in April 2009. |
T465 |
4258-4421 |
Sentence |
denotes |
As a result, ten swine having severe disease were sacrificed for necropsy which identified lesions in the bronchioles corresponding to the influenza virus disease. |
T466 |
4422-4487 |
Sentence |
denotes |
Virus isolation and sequencing identified the A(H1N1)pdm09 virus. |
T467 |
4488-4660 |
Sentence |
denotes |
Additionally, A(H1N1)pdm09 virus was identified in two more human subjects who were exposed to the swine hence indicated the occurrence of zoonoses on the swine farm [254]. |
T468 |
4661-4765 |
Sentence |
denotes |
Later during summer 2009, ten more A(H1N1)pdm09 viruses from five swine herds in Manitoba were reported. |
T469 |
4766-4884 |
Sentence |
denotes |
Virus shedding was observed up to 20 days post-infection after the appearance of the clinical symptoms in swine [255]. |
T470 |
4885-5116 |
Sentence |
denotes |
This observation was in agreement of a previous report which documented the experimental infection of swine in the laboratory and determined that virus shedding occurs until 11th day after appearance of the clinical symptoms [256]. |
T471 |
5117-5281 |
Sentence |
denotes |
Another investigation reported nine A(H1N1)pdm09 and four H3N2 viruses after an influenza-like disease outbreak on a Quebec based swine farm in December 2010 [257]. |
T472 |
5282-5577 |
Sentence |
denotes |
The effect of microclimatic conditions on the transmission dynamics of swine IAV in the barns was studied which observed that high relative humidity in the environment during summer months suppresses the aerosol transmission of the droplets which in turn decreases the transmission of IAV [240]. |
T473 |
5578-5850 |
Sentence |
denotes |
The high relative humidity in the environment would facilitate the generation of larger droplets which do not tend to shrink easily and hence are less likely to be aerosol transmitted to a longer distance as they fall on the ground quickly after their formation [240,258]. |
T474 |
5851-5937 |
Sentence |
denotes |
As a result, a lower transmission of IAV is observed usually during the summer months. |
T475 |
5938-6056 |
Sentence |
denotes |
On the contrary, the IAV transmission increases during winter months when relative humidity is relatively lower [258]. |