| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T93 |
0-116 |
Sentence |
denotes |
Non-structural protein 15 (Nsp15) of SARS-CoV-2 is an endoribonuclease that preferentially cleaves RNA at uridylate. |
| T94 |
117-224 |
Sentence |
denotes |
Furthermore, it has been shown that SARS-CoV Nsp15/NendoU is required for successful viral infection [109]. |
| T95 |
225-450 |
Sentence |
denotes |
The best docking ligands for SARS-CoV Nsp15/NendoU are (E,E)-α-farnesene (DSnorm = −107.5 kJ/mol), (E)-β-farnesene (DSnorm = −105.0 kJ/mol), (E,E)-farnesol (DSnorm = −104.6 kJ/mol), and (E)-nerolidol (DSnorm = −101.6 kJ/mol). |
| T96 |
451-644 |
Sentence |
denotes |
All of these sesquiterpenoids preferentially docked into a binding site formed by amino acid residues Gln347, Ile328, Val276, Ser274, Thr275, Ser329, Asn74, Asn75, Glu327, and Lys71 (Figure 3). |
| T97 |
645-832 |
Sentence |
denotes |
In addition to van der Waals interactions, (E,E)-farnesol showed hydrogen-bonding interactions with Ser329 and Glu327, while (E)-nerolidol hydrogen bonded with Asn75 and Lys71 (Figure 3). |
| T98 |
833-1029 |
Sentence |
denotes |
Unfortunately, the docking scores for these ligands as well as the scores of the other essential oil components with this protein are too low for it to be considered a viable target (see Table 3). |
