| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T34 |
0-197 |
Sentence |
denotes |
From a biochemical perspective, a conserved nAChR-binding motif within the primary amino acid sequences of the RABV glycoprotein, HIV-1 gp120, and snake venom neurotoxins has been observed [31–33]. |
| T35 |
198-405 |
Sentence |
denotes |
The HIV-1 envelope, gp120, has been reported to induce neuropathological changes similar to those in patients with HIV-1-associated neurocognitive disorders and triggers an upregulation of the α7-nAChR [34]. |
| T36 |
406-518 |
Sentence |
denotes |
Importantly, snake venom toxins have been demonstrated to be high-affinity competitive antagonists of the nAChR. |
| T37 |
519-775 |
Sentence |
denotes |
Sequence analysis of the SARS-CoV-2 spike protein identified homologous regions of 4-5 amino acids with aligned sequences in alpha-bungarotoxin and alpha-cobratoxin, thereby suggesting potential binding affinity and antagonism of the α7-nACh receptor [11]. |
| T38 |
776-986 |
Sentence |
denotes |
Sequence homologies between putative nAChR-binding domains within the SARS-CoV-2 spike protein and HIV-1 gp120 have yet to be determined, although there are recent indications for shared CNS comorbidities [35]. |
| T39 |
987-1275 |
Sentence |
denotes |
In sum, convergent lines of evidence presented here support the potential construction and testing of novel homologous vaccines employing non-replicating RABV particles expressing chimeric capsid proteins containing antigenic sequences from SARS-CoV-2 spike protein and RABV glycoprotein. |
