LitCovid-sentences  

PMC:7275193 / 2029-7456 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T16 0-17 Sentence denotes Case Presentation
T17 18-266 Sentence denotes A 65-year-old male with accelerated phase chronic myelogenous leukemia (AP-CML) presented to the emergency department with a 3-day history of febrile sensation (not measured by the patient) and progressive shortness of breath, mainly with exertion.
T18 267-396 Sentence denotes Also, he had had a productive cough with a small amount of yellowish sputum and intermittent pleuritic chest pain for a few days.
T19 397-508 Sentence denotes He denied any history of runny nose, sore throat, loss of smell or taste sense, night sweating, or weight loss.
T20 509-605 Sentence denotes There was no history of contact with sick patients, especially with COVID-19, nor recent travel.
T21 606-841 Sentence denotes He had had AP-CML for 4 years, currently in major molecular remission, and the latest BCR-ABL level was 0.04%; he was on dasatinib 140 mg but decreased to 100 mg because he had pancytopenia, which was resolved after adjusting the dose.
T22 842-953 Sentence denotes Also, he had a chronic right-sided small loculated pleural effusion which was attributed to dasatinib (Fig. 1).
T23 954-1050 Sentence denotes On arrival to the emergency department, he was febrile, and his recorded temperature was 38.4°C.
T24 1051-1245 Sentence denotes He had an oxygen saturation (SpO2) of 94% on 6 L via a nonrebreather mask, a respiratory rate of 19 breath per minute, a heart rate of 104 beats per minute, and a blood pressure of 138/79 mm Hg.
T25 1246-1291 Sentence denotes He was conscious, oriented, and feeling well.
T26 1292-1417 Sentence denotes Breath sounds were decreased on the bilateral lower lung fields with a coarse crepitation in the right middle to lower zones.
T27 1418-1468 Sentence denotes The examination of other systems was unremarkable.
T28 1469-1573 Sentence denotes Laboratory findings (on the admission day) showed pancytopenia, increased PTT, INR and elevated D-dimer.
T29 1574-1617 Sentence denotes The liver and kidney functions were normal.
T30 1618-1691 Sentence denotes C-reactive protein level was elevated and LDH level was normal (Table 1).
T31 1692-1864 Sentence denotes The chest X-ray showed bilateral lower lobe collapse and consolidation with pleural effusion, more noted on the left side, which is increased compared to baseline (Fig. 2).
T32 1865-2004 Sentence denotes Considering the patient's background, clinical presentation and the current pandemic, we tested him for COVID-19 and it came back positive.
T33 2005-2288 Sentence denotes Chest computed tomography (CT) showed bilateral pleural effusions evident on the left side with lower lobe subsegmental collapse and consolidation as a consequence as well as likely right anterior empyema formation and bilateral lower lung lobe post-inflammatory changes (Fig. 3, 4).
T34 2289-2338 Sentence denotes There was no growth in blood nor sputum cultures.
T35 2339-2392 Sentence denotes Also, acid fast bacilli smears and PCR were negative.
T36 2393-2684 Sentence denotes The patient was admitted with neutropenic fever and COVID-19 and was initially started on hydroxychloroquine 400 mg orally daily, azithromycin 500 mg p.o. daily, oseltamivir 150 mg p.o. b.i.d., based on local COVID-19 management protocol, and piperacillin/tazobactam 4,500 mg i.v. every 8 h.
T37 2685-2750 Sentence denotes Dasatinib was kept on hold as recommended by the hematology team.
T38 2751-2869 Sentence denotes Diagnostic thoracocentesis was done to rule out other underlying causes, 500 mL was removed, and a drain was inserted.
T39 2870-2995 Sentence denotes Pleural fluid analysis showed exudative lymphocytic pleural effusion and negative acid fast bacilli smears, PCR and cultures.
T40 2996-3081 Sentence denotes On day 4, he started to improve, and he was off oxygen; his SpO2 was 95% on room air.
T41 3082-3128 Sentence denotes However, he became more neutropenic (Table 2).
T42 3129-3231 Sentence denotes On day 8, he had dyspnea after coming back from the bathroom, and became tachypneic (respiratory rate:
T43 3232-3283 Sentence denotes 43 breaths per minute) and tachycardic (heart rate:
T44 3284-3396 Sentence denotes 115 beats per minute), requiring 10 L of oxygen via the nonrebreather mask to maintain his SpO2 level above 94%.
T45 3397-3493 Sentence denotes Chest auscultation showed diffuse bilateral crackles, and there were no signs of fluid overload.
T46 3494-3548 Sentence denotes Arterial blood gas results were pH 7.48 (normal range:
T47 3549-3588 Sentence denotes 7.35–7.45), pO2 63 mm Hg (normal range:
T48 3589-3629 Sentence denotes 83–108), HCO3 27.4 mmol/L (normal range:
T49 3630-3669 Sentence denotes 23–27) and pCO2 34 mm Hg (normal range:
T50 3670-3677 Sentence denotes 35–45).
T51 3678-3771 Sentence denotes The patient was given oxygen and salbutamol nebulization but without significant improvement.
T52 3772-3884 Sentence denotes The repeated chest X-ray (Fig. 5) showed bilateral infiltrations and his calculated PaO2/FiO2 ratio = 143 (PaO2:
T53 3885-3913 Sentence denotes 63 on 6 L oxygen, FiO2 44%).
T54 3914-3984 Sentence denotes Cardiac causes have been ruled out, so he fulfilled the ARDS criteria.
T55 3985-4091 Sentence denotes Moreover, he was still neutropenic, and his ferritin, LDH and triglyceride levels were elevated (Table 3).
T56 4092-4151 Sentence denotes So, the patient was transferred to the intensive care unit.
T57 4152-4305 Sentence denotes The infectious disease team recommended to manage him as a case of severe COVID-19 pneumonia complicated by ARDS, which might be due to a cytokine storm.
T58 4306-4533 Sentence denotes Therefore, they added ritonavir plus lopinavir 500 mg orally daily for 14 days, tocilizumab 400 mg i.v. single dose, and methylprednisolone 40 mg i.v. every 12 h for 5 days, and BiPAP has been applied to improve his SpO2 level.
T59 4534-4689 Sentence denotes After a few hours, he started to improve with this regimen, so he was shifted back to a simple face mask, and gradually the amount of oxygen has decreased.
T60 4690-4748 Sentence denotes The repeated ABG showed an improvement in pO2 (100 mm Hg).
T61 4749-4913 Sentence denotes On day 12, the chest X-ray was repeated and showed satisfactory lung field expansion with no significant interval change regarding the bilateral airspace opacities.
T62 4914-5032 Sentence denotes Right-sided pleural effusion is still noted with progression in the segmental right lower lung zone collapse (Fig. 6).
T63 5033-5130 Sentence denotes After completion of the treatment, he has gradually improved, and his SpO2 is 98% on ambient air.
T64 5131-5271 Sentence denotes However, his ANC is fluctuating between 0.4 and 1.8 × 103/μL and he was on daily filgrastim (Fig. 7), so dasatinib has not been started yet.
T65 5272-5382 Sentence denotes He is still in the hospital but off medications and waiting for his repeated PCR to be negative for discharge.
T66 5383-5427 Sentence denotes The latest one was done on day 30 (Table 4).