LitCovid-sentences  

PMC:7274970 / 2840-6594 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T20 0-15 Sentence denotes 1 Introduction
T21 16-106 Sentence denotes Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread worldwide.
T22 107-312 Sentence denotes COVID-19 is highly contagious and can result in acute respiratory distress, multiple organ failure, or death in severe cases (Huang et al., 2020a, Wang et al., 2020, Yang et al., 2020, Zhang et al., 2020).
T23 313-498 Sentence denotes The reported mortality rate of COVID-19 is lower than that of severe acute respiratory syndrome (SARS) (Donnelly et al., 2003), or Middle East respiratory syndrome (MERS) (Ahmed, 2017).
T24 499-814 Sentence denotes However, the number of patients needing urgent critical care is remarkably larger than previous outbreaks of SARS or MERS, which could lead to a critical shortage of intensive care unit (ICU) beds and specialized medical and nursing personnel, and, consequently, result in the collapse of local health care systems.
T25 815-1002 Sentence denotes Thus, timely and appropriate dynamic monitoring and treatment for non-ICU inpatients is urgent and necessary to reduce the risk of patients becoming critically ill and requiring ICU care.
T26 1003-1131 Sentence denotes Patients with COVID-19 typically present a decrease in absolute lymphocyte count (ALC) (Huang et al., 2020a, Wang et al., 2020).
T27 1132-1364 Sentence denotes The dynamic profile of total circulating lymphocytes indicated that a continuous and sustained decrease in the ALC is closely associated with disease aggravation and death in COVID-19 patients (Wang et al., 2020, Zhou et al., 2020).
T28 1365-1463 Sentence denotes Indeed, lymphopenia was associated with increased disease severity in COVID-19 (Tan et al., 2020).
T29 1464-1746 Sentence denotes In addition, the neutrophil-to-lymphocyte ratio (NLR) can also serve as a simple complementary indicator to predict clinical severity and prognosis, and is an independent risk factor for mortality in patients with COVID-19 (Lagunas-Rangel, 2020, Qin et al., 2020, Liu et al., 2020).
T30 1747-1952 Sentence denotes These studies indicate that promoting recovery from lymphopenia and slowing the deterioration based on an increased NLR may reduce the need for ICU care and improve the prognosis of patients with COVID-19.
T31 1953-2065 Sentence denotes To date, no specific drugs have been shown to be effective in alleviating lymphopenia in patients with COVID-19.
T32 2066-2360 Sentence denotes Sleep is a physiological and behavioral process required for survival and plays an important role in metabolism and immune system homeostasis (Besedovsky et al., 2019, Haspel et al., 2020, Mukherjee et al., 2015); indeed, sleep and immunity are bidirectionally linked (Besedovsky et al., 2019).
T33 2361-2607 Sentence denotes Sleep disturbance impairs innate and adaptive immune responses and activates inflammation, with an increase in circulating inflammatory cytokines due to disruption of the circadian rhythms (Haack et al., 2007, Irwin, 2015, Vgontzas et al., 2004).
T34 2608-2733 Sentence denotes Short-term sleep deprivation is associated with compromised natural killer cell activity in the blood (Fondell et al., 2011).
T35 2734-2972 Sentence denotes Disruption of the circadian rhythm of sleep, shorter sleep duration, or poor quality of sleep could increase susceptibility to upper respiratory infections (Cohen et al., 2009, Loef et al., 2019, Patel et al., 2012, Prather et al., 2015).
T36 2973-3079 Sentence denotes In fact, septic patients with frequently disrupted sleep have higher mortality rates (Huang et al., 2014).
T37 3080-3378 Sentence denotes Sleep impairment occurs frequent in patients with COVID-19 (Liguori et al., 2020), which may be due to isolated environment without family member’ companion, physical discomfort caused by the illness, or psychological factor (fear, anxiety, helplessness and/or depression, etc.) (Guo et al., 2020).
T38 3379-3542 Sentence denotes However, there are currently no reports of the effects of sleep quality during hospitalization on immune function recovery and prognosis in patients with COVID-19.
T39 3543-3754 Sentence denotes In tour study, we aimed to describe the effects of self-reported sleep quality on recovery from lymphopenia, deterioration based on an increased NLR, and clinical outcomes in hospitalized patients with COVID-19.