| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T55 |
0-129 |
Sentence |
denotes |
SARS‐CoV‐2 uses angiotensin converting enzyme‐2 (ACE2) as its receptor on human cells, and binding to this facilitates infection. |
| T56 |
130-429 |
Sentence |
denotes |
16 The mammalian serine protease TMPRSS2 or the protease Furin (also known as Paired basic Amino acid Cleaving Enzyme) appear to prime the spike protein for interaction with ACE2.17, 18 SARS‐CoV also binds to the cell‐surface protein ACE2 and this binding is required for the virus to infect cells. |
| T57 |
430-595 |
Sentence |
denotes |
19 The binding of SARS‐CoV‐2 to ACE2 is enhanced compared to that of SARS‐CoV due to several changes in the gene and hence amino acid sequence of the spike protein. |
| T58 |
596-876 |
Sentence |
denotes |
20 SARS‐CoV also binds to CD209 (dendritic cell [DC]‐specific intercellular adhesion molecule [ICAM‐3] grabbing non‐integrin; DC‐SIGN) and CD209L (L‐SIGN).21, 22, 23 MERS‐CoV binds to the cell‐surface molecule CD26 (DPP‐4) and this is facilitated by the cofactor CD66e (CEACAM5). |
| T59 |
877-879 |
Sentence |
denotes |
24 |
