PMC:7272971 / 120-2156 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T5 0-147 Sentence denotes The ocular surface has been suggested as a site of infection with Coronavirus‐2 (SARS‐CoV‐2) responsible for the coronavirus disease‐19 (COVID‐19).
T6 148-246 Sentence denotes This review examines the evidence for this hypothesis, and its implications for clinical practice.
T7 247-461 Sentence denotes Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2), responsible for the COVID‐19 pandemic, is transmitted by person‐to‐person contact, via airborne droplets, or through contact with contaminated surfaces.
T8 462-555 Sentence denotes SARS‐CoV‐2 binds to angiotensin converting enzyme‐2 (ACE2) to facilitate infection in humans.
T9 556-645 Sentence denotes This review sets out to evaluate evidence for the ocular surface as a route of infection.
T10 646-736 Sentence denotes A literature search in this area was conducted on 15 April 2020 using the Scopus database.
T11 737-786 Sentence denotes In total, 287 results were returned and reviewed.
T12 787-989 Sentence denotes There is preliminary evidence for ACE2 expression on corneal and conjunctival cells, but most of the other receptors to which coronaviruses bind appear to be found under epithelia of the ocular surface.
T13 990-1146 Sentence denotes Evidence from animal studies is limited, with a single study suggesting viral particles on the eye can travel to the lung, resulting in very mild infection.
T14 1147-1344 Sentence denotes Coronavirus infection is rarely associated with conjunctivitis, with occasional cases reported in patients with confirmed COVID‐19, along with isolated cases of conjunctivitis as a presenting sign.
T15 1345-1418 Sentence denotes Coronaviruses have been rarely isolated from tears or conjunctival swabs.
T16 1419-1522 Sentence denotes The evidence suggests coronaviruses are unlikely to bind to ocular surface cells to initiate infection.
T17 1523-1699 Sentence denotes Additionally, hypotheses that the virus could travel from the nasopharynx or through the conjunctival capillaries to the ocular surface during infection are probably incorrect.
T18 1700-1840 Sentence denotes Conjunctivitis and isolation of the virus from the ocular surface occur only rarely, and overwhelmingly in patients with confirmed COVID‐19.
T19 1841-2036 Sentence denotes Necessary precautions to prevent person‐to‐person transmission should be employed in clinical practice throughout the pandemic, and patients should be reminded to maintain good hygiene practices.