LitCovid-sentences  

PMC:7271924 / 972-4316 JSONTXT 14 Projects

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Id Subject Object Predicate Lexical cue
T9 0-12 Sentence denotes Introduction
T10 13-179 Sentence denotes Lactoferrin (LF) or lactotransferrin has recently come under the spotlight, particularly with regards to the new coronavirus pandemic that started in 2019 (COVID-19).
T11 180-305 Sentence denotes Diet and supplements support a well-functioning immune system, and favorably influence the body's ability to fight infection.
T12 306-559 Sentence denotes Although LF is produced by the body itself, as a secretion by exocrine glands (such as maternal milk or tears) and secondary granules of human neutrophils (1), it can also be taken as a supplement, where it then acts as nutraceutical or functional food.
T13 560-618 Sentence denotes Our particular focus is on its role as an oral supplement.
T14 619-845 Sentence denotes Here we also collate some of the evidence that shows how LF may be an important nutrient to support host immunity, including as an antibacterial and antiviral agent, but particularly with the current COVID-19 pandemic in mind.
T15 846-985 Sentence denotes We summarize what is already known about LF, including its immunological properties, as well as its antibacterial and antiviral activities.
T16 986-1089 Sentence denotes We also discuss how LF uses Heparan Sulfate Proteoglycans (HSPGs) on cell surfaces to facilitate entry.
T17 1090-1291 Sentence denotes This is of particular importance to coronaviruses, as these viruses are considered to bind to the host cell by attaching first to HSPGs using them as preliminary docking sites on the host cell surface.
T18 1292-1456 Sentence denotes LF is known to interfere with some of the receptors used by coronaviruses, it may thus contribute usefully to the prevention and treatment of SARS CoV-2 infections.
T19 1457-1691 Sentence denotes In COVID-19 infection, LF may therefore have a role to play, not only sequestering iron and inflammatory molecules that are severely increased during the cytokine burst, but also possibly in assisting by occupying receptors and HSPGs.
T20 1692-1866 Sentence denotes LF might also prevent virus accumulation by the host cell, as well as rolling activity and entering of the virus via the host receptor angiotensin-converting enzyme 2 (ACE2).
T21 1867-2050 Sentence denotes It has been 20 years since the discovery of ACE2, and since its discovery it has been found to be expressed in numerous tissues, including the lungs and the cardiovascular system (2).
T22 2051-2202 Sentence denotes During 2020, there has been a renewed interest in this receptor, due to the interactions of novel coronaviruses and their interactions with ACE2 (3–5).
T23 2203-2319 Sentence denotes South and co-workers in 2020 also investigated whether ACE2 blockade is a suitable option to attenuate COVID-19 (5).
T24 2320-2436 Sentence denotes The use of recombinant human ACE2 (rhACE2) as ACE receptor competitor for binding has also been investigated (6, 7).
T25 2437-2604 Sentence denotes There is also interest in the therapeutic targeting of HSPGs, and Hondermarck and co-workers suggested that is seems an easy way to inhibit SARS-Cov-2 infectivity (8).
T26 2605-2800 Sentence denotes Here we also suggest that LF might be used as both a preventive and therapeutic supplement in the COVID-19 pandemic, by preventing interactions between the virus and both HSPGs and possibly ACE2.
T27 2801-2851 Sentence denotes We summarize the layout of this paper in Figure 1.
T28 2852-2906 Sentence denotes Figure 1 Overview of this review of lactoferrin (LF).
T29 2907-3292 Sentence denotes We discuss (1) discovery and structure of LF; (2) LF membrane receptors and some of the bacteria, their products and viruses that might also bind to these receptors, (3) including how acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (causing COVID-19) may interact with host cells (see Figure 6 and Conclusion for a detailed discussion); (4) and how LF assists with host immunity.
T30 3293-3344 Sentence denotes Diagram created with BioRender (www.biorender.com).