| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T68 |
0-107 |
Sentence |
denotes |
LF is thought to exert its main biological activities following interaction with receptors on target cells. |
| T69 |
108-211 |
Sentence |
denotes |
There are in fact many LF receptors, though sometimes one is referred to as “the” lactoferrin receptor. |
| T70 |
212-334 |
Sentence |
denotes |
They have been detected in multiple tissues and cell types including intestinal epithelial cells and lymphocytes (60, 61). |
| T71 |
335-550 |
Sentence |
denotes |
Receptors that bind LF include CD14 (62), LDL receptor-related protein-1 (LRP-1/CD91) (63–65) intelectin-1 (omentin-1) (66), Toll-like receptor 2 and 4 (TLR4) (67) and cytokine receptor 4 (CXCR4) (68) (see Table 2). |
| T72 |
551-800 |
Sentence |
denotes |
Importantly, LF also binds to heparan sulfate proteoglycans (HSPGs), which are cell-surface and extracellular matrix macromolecules that are composed of a core protein decorated with covalently linked glycosaminoglycan (GAG) chains (86, 87, 98, 99). |
| T73 |
801-813 |
Sentence |
denotes |
See Table 2. |
| T74 |
814-1111 |
Sentence |
denotes |
Different receptors express at vastly different levels in different tissues; thus intelectin-1 is really expressed only in the intestine (https://www.proteinatlas.org/ENSG00000179914-ITLN1/tissue), while LRP1 is far more widely distributed https://www.proteinatlas.org/ENSG00000123384-LRP1/tissue. |
| T75 |
1112-1317 |
Sentence |
denotes |
These multiple receptors arguably underpin the substantial and widespread effects that LF can induce, since only when multiple targets are hit simultaneously can one normally have major effects (103, 104). |
