LitCovid-sentences  

PMC:7271924 / 28556-30124 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T224 0-112 Sentence denotes Lactoferrin clearly has immunological benefits, as well as having an important antibacterial and antiviral role.
T225 113-281 Sentence denotes Because it is known to interfere with some of the receptors used by coronaviruses, it may contribute usefully to the prevention and treatment of coronavirus infections.
T226 282-365 Sentence denotes Figure 6 shows a possible scheme on how LF might interfere with SARS-CoV-2 binding.
T227 366-493 Sentence denotes The binding of LF to HSPGs prevents the first contact between virus and host cells and thus prevents subsequent infection (99).
T228 494-549 Sentence denotes HSPGs themselves are not sufficient for SARS-CoV entry.
T229 550-650 Sentence denotes However, in SARS-CoV infections, the HSPGs play an important role in the process of cell entry (99).
T230 651-802 Sentence denotes The anchoring sites provided by HSPGs permit initial contact between the virus and host cells and the concentration of virus particles on cell surface.
T231 803-943 Sentence denotes SARS-CoV bound to HSPGs then rolls onto the cell membrane and scans for specific entry receptors, which leads to subsequent cell entry (99).
T232 944-1133 Sentence denotes LF enhances natural killer cell activity and stimulates neutrophil aggregation and adhesion in immune defense (135) and can restrict the entry of the virus into host cells during infection.
T233 1134-1302 Sentence denotes We suggest that this process might be the same for COVID-19 (see Figure 6 for a visual representation), thereby offering useful strategies for prevention and treatment.
T234 1303-1413 Sentence denotes Currently, there is also a renewed interest in ACE2 and HSPG blocking, as discussed in the introduction (5–8).
T235 1414-1568 Sentence denotes LF may therefore be an excellent supplement to take, not only as a contribution to prevention but perhaps as a therapy in the event COVID-19 is diagnosed.