LitCovid-sentences  

PMC:7271924 / 28544-31050 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T223 0-11 Sentence denotes Conclusions
T224 12-124 Sentence denotes Lactoferrin clearly has immunological benefits, as well as having an important antibacterial and antiviral role.
T225 125-293 Sentence denotes Because it is known to interfere with some of the receptors used by coronaviruses, it may contribute usefully to the prevention and treatment of coronavirus infections.
T226 294-377 Sentence denotes Figure 6 shows a possible scheme on how LF might interfere with SARS-CoV-2 binding.
T227 378-505 Sentence denotes The binding of LF to HSPGs prevents the first contact between virus and host cells and thus prevents subsequent infection (99).
T228 506-561 Sentence denotes HSPGs themselves are not sufficient for SARS-CoV entry.
T229 562-662 Sentence denotes However, in SARS-CoV infections, the HSPGs play an important role in the process of cell entry (99).
T230 663-814 Sentence denotes The anchoring sites provided by HSPGs permit initial contact between the virus and host cells and the concentration of virus particles on cell surface.
T231 815-955 Sentence denotes SARS-CoV bound to HSPGs then rolls onto the cell membrane and scans for specific entry receptors, which leads to subsequent cell entry (99).
T232 956-1145 Sentence denotes LF enhances natural killer cell activity and stimulates neutrophil aggregation and adhesion in immune defense (135) and can restrict the entry of the virus into host cells during infection.
T233 1146-1314 Sentence denotes We suggest that this process might be the same for COVID-19 (see Figure 6 for a visual representation), thereby offering useful strategies for prevention and treatment.
T234 1315-1425 Sentence denotes Currently, there is also a renewed interest in ACE2 and HSPG blocking, as discussed in the introduction (5–8).
T235 1426-1580 Sentence denotes LF may therefore be an excellent supplement to take, not only as a contribution to prevention but perhaps as a therapy in the event COVID-19 is diagnosed.
T236 1581-1797 Sentence denotes Figure 6 Possible action of (1) lactoferrin by occupying binding sites of (2) SARS-CoV-2 that causes COVID-19. (3) Entry into host cells occur when SARS-CoV-2 first attaches to Heparan sulfate proteoglycans (HSPGs).
T237 1798-2445 Sentence denotes This attachment initiates the first contact between the cell and the virus, concentrating the virus on the cell surface, (4) followed attaching of the virus to the host receptor (ACE2) and association and entering are then facilitated via clathrin-coated pits (5) Virus replication can then happen inside the cell. (6) One of the characteristics of Lactoferrin, is that it attaches to HSPGs. (7) Currently we do not know if ACE2 is also a receptor for lactoferrin. (8) Lactoferrin may block the entry of SARS-CoV-2 into the host cell, by occupying HPSGs, thereby preventing SARS-CoV-2 initial attachment and accumulation on the host cell membrane.
T238 2446-2506 Sentence denotes COVID-19 infection template adjusted from www.biorender.com.