PMC:7271924 / 21279-22358 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T167 0-130 Sentence denotes The 2003 SARS-CoV strain, that also causes severe acute respiratory syndrome, attaches to host cells via host receptor ACE2 (171).
T168 131-302 Sentence denotes This type I integral membrane protein receptor is a well-known receptor for respiratory viruses, and is abundantly expressed in tissues lining the respiratory tract (111).
T169 303-392 Sentence denotes During COVID-19 infection, SARS-CoV-2 also enters host cells via the ACE2 receptor (172).
T170 393-565 Sentence denotes ACE2 is highly expressed on human lung alveolar epithelial cells, enterocytes of the small intestine, and the brush border of the proximal tubular cells of the kidney (99).
T171 566-713 Sentence denotes HSPGs are also one of the preliminary docking sites on the host cell surface and play an important role in the process of SARS-CoV cell entry (99).
T172 714-858 Sentence denotes There is no current confirmed information that SARS-CoV-2 binds to HSPGs, however, LF blocks the infection of SARS-CoV by binding to HSPGs (99).
T173 859-942 Sentence denotes It is not presently known whether LF binds to ACE2, but it does bind to HSPGs (99).
T174 943-1079 Sentence denotes Whether SARS-CoV-2 also enters host cells via HPSGs in the same way, as does (the 2003) SARS-CoV clearly warrants further investigation.