Id |
Subject |
Object |
Predicate |
Lexical cue |
T153 |
0-23 |
Sentence |
denotes |
Viruses and Lactoferrin |
T154 |
24-144 |
Sentence |
denotes |
LF has strong antiviral activity against a broad spectrum of both naked and enveloped DNA and RNA viruses (99, 149–151). |
T155 |
145-335 |
Sentence |
denotes |
LF inhibits the entry of viral particles into host cells, either by direct attachment to the viral particles or by blocking their cellular receptors (discussed in previous paragraphs) (149). |
T156 |
336-522 |
Sentence |
denotes |
Some of the viruses that LF prevents from entering host cells e.g., Herpes simplex virus (162), human papillomavirus (163), human immunodeficiency virus (HIV) (164), and rotavirus (165). |
T157 |
523-661 |
Sentence |
denotes |
These viruses typically utilize common molecules on the cell membrane to facilitate their invasion into cells, including HSPGs (Figure 1). |
T158 |
662-795 |
Sentence |
denotes |
HSPGs provide the first anchoring sites on the host cell surface, and help the virus make primary contact with these cells (99, 162). |
T159 |
796-894 |
Sentence |
denotes |
HSPGs can be either membrane bound, or in secretory vesicles and in the extracellular matrix (86). |
T160 |
895-1001 |
Sentence |
denotes |
It has been shown that LF is able to prevent the internalization of some viruses by binding to HSPGs (86). |