| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T144 |
0-184 |
Sentence |
denotes |
Several Gram-negative pathogens including members of the genera Neisseria and Moraxella have evolved two-component systems that can extract iron from the host LF and transferrin (157). |
| T145 |
185-258 |
Sentence |
denotes |
N. meningitidis is a principal cause of bacterial meningitis in children. |
| T146 |
259-505 |
Sentence |
denotes |
While the majority of pathogenic bacteria employ siderophores to chelate and scavenge iron (158), Neisseria has evolved a series of protein transporters that directly hijack iron sequestered in host transferrin, lactoferrin, and hemoglobin (159). |
| T147 |
506-808 |
Sentence |
denotes |
The system consists of a membrane-bound transporter that extracts and transports iron across the outer membrane (TbpA for transferrin and LbpA for lactoferrin), and a lipoprotein that delivers iron-loaded lactoferrin/transferrin to the transporter (TbpB for transferrin and LbpB for lactoferrin) (157). |
| T148 |
809-898 |
Sentence |
denotes |
LbpB binds the N-lobe of lactoferrin, whereas TbpB binds the C-lobe of transferrin (157). |
| T149 |
899-1111 |
Sentence |
denotes |
However, more than 90% of LF in human milk is in the form of apolactoferrin (160), which competes with siderophilic bacteria for ferric iron, and disrupts the proliferation of these microbial and other pathogens. |
| T150 |
1112-1198 |
Sentence |
denotes |
Similarly LF supplements may play an important role to counteract bacterial processes. |
| T151 |
1199-1315 |
Sentence |
denotes |
LF is consequently a significant element of host defense (19), and its levels may vary in health and during disease. |
| T152 |
1316-1398 |
Sentence |
denotes |
It is hence known to be a modulator of innate and adaptive immune responses (161). |
