LitCovid-sentences  

PMC:7271924 / 13843-15607 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T109 0-27 Sentence denotes Neutrophils and Lactoferrin
T110 28-114 Sentence denotes LF plays an important role in host defense, upon its release from the neutrophil (26).
T111 115-258 Sentence denotes LF also enhances natural killer cell activity in immune defense (135) and can restrict the entry of the virus into host cells during infection.
T112 259-399 Sentence denotes As part of the host's inflammatory response, leucocytes, including neutrophils, release LF from their granules, where it is normally stored.
T113 400-556 Sentence denotes Activated neutrophils also release chromatin fibers, known as neutrophil extracellular traps (NETs), which trap and kill, amongst others, bacteria (1, 136).
T114 557-633 Sentence denotes These NETs likewise modulate both acute and chronic inflammation (137, 138).
T115 634-757 Sentence denotes NETs are also found in various autoimmune conditions such as rheumatoid arthritis, systemic lupus erythematosus (139, 140).
T116 758-824 Sentence denotes Interestingly, 106 human neutrophils can release 15 μg of LF (26).
T117 825-966 Sentence denotes In addition to DNA and histones, NET fibers contain extranuclear proteins and proteins such as elastase, myeloperoxidase (MPO), and LF (141).
T118 967-1110 Sentence denotes LF may also serve as an intrinsic inhibitor of NETs release into the circulation, and may therefore be central in controlling NETs release (1).
T119 1111-1124 Sentence denotes See Figure 3.
T120 1125-1439 Sentence denotes Figure 3 Bacterial binding to various receptors, e.g., Toll-like receptors 2 and 4 (TLR2 and 4), as well as complement receptors, leads to protein arginine deiminase 4 (PAD4) activation, followed by chromatin decondensation, hypercitrullination of histones 3 and 4 in the nucleus, and nuclear membrane disruption.
T121 1440-1474 Sentence denotes Granules also release lactoferrin.
T122 1475-1601 Sentence denotes Neutrophil Extracellular Traps (NETs) and their protein constituents (including lactoferrin) are released from the neutrophil.
T123 1602-1660 Sentence denotes Adapted from Jorch and Kubes (142) and Law and Gray (143).
T124 1661-1707 Sentence denotes Bacteria are expelled and trapped in the NETs.
T125 1708-1764 Sentence denotes Diagram created with BioRender (https://biorender.com/).