Id |
Subject |
Object |
Predicate |
Lexical cue |
T143 |
0-13 |
Sentence |
denotes |
4 DISCUSSION |
T144 |
14-166 |
Sentence |
denotes |
Patients with ARDS triggered by viral infection, in particular influenza, are prone to invasive aspergillosis even in absence of prior immunodeficiency. |
T145 |
167-326 |
Sentence |
denotes |
2 , 3 We report putative IPA in five of 19 COVID‐19 patients with moderate to severe ARDS without underlying immunocompromising disease on two separate ICUs. |
T146 |
327-412 |
Sentence |
denotes |
Spontaneous intrapulmonary bleeding and haemoptysis are typical complications of IPA. |
T147 |
413-544 |
Sentence |
denotes |
Ground‐glass opacities characterise COVID‐19 as well as IPA, thus comprehensive microbiological evaluation can prevent missing IPA. |
T148 |
545-809 |
Sentence |
denotes |
By applying strict interpretation of the host and risk factors for invasive aspergillosis according to the European Organization for Research and Treatment of Cancer/Mycoses Study Group definitions the risk of missed diagnosis increases in the COVID‐19 population. |
T149 |
810-982 |
Sentence |
denotes |
8 However, a most complicated issue in ARDS patients is to differentiate Aspergillus colonisation from invasive disease—especially as radiological imaging is non‐specific. |
T150 |
983-1129 |
Sentence |
denotes |
To address this issue, a consensus project will seek to provide standard definitions for invasive fungal disease in critically ill adult patients. |
T151 |
1130-1132 |
Sentence |
denotes |
10 |
T152 |
1133-1304 |
Sentence |
denotes |
Our observations suggest increased risk for critically ill COVID‐19 patients to develop co‐infection with Aspergillus, which is likely to increase mortality rates further. |
T153 |
1305-1481 |
Sentence |
denotes |
Therefore, testing for the presence of Aspergillus in lower respiratory secretions and galactomannan in consecutive serum samples in COVID‐19 ICU patients should be considered. |
T154 |
1482-1484 |
Sentence |
denotes |
11 |
T155 |
1485-1592 |
Sentence |
denotes |
Our findings need to be confirmed in clinical trials to elucidate the role of potential IPA after COVID‐19. |
T156 |
1593-1706 |
Sentence |
denotes |
With this report, we aim to call attention to the critical phenomenon of COVID‐19 associated IA in ARDS patients. |