LitCovid-sentences  

PMC:7264932 / 79-4637 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2 0-14 Sentence denotes To the editor,
T3 15-168 Sentence denotes Superinfections, including invasive pulmonary aspergillosis (IPA), are well-known complications of severe viral pneumonia in critically ill patients [1].
T4 169-511 Sentence denotes Pathological studies of individuals with severe coronavirus disease 2019 (COVID-19) -associated acute respiratory distress syndrome reported diffuse alveolar damage combined with intra-alveolar neutrophilic infiltration and vascular congestion, assuming an impaired mucociliary activity that might pave the way for secondary infections [2,3].
T5 512-690 Sentence denotes Our report of two critically ill patients suggests that IPA might be a relevant complication of severe COVID-19 pneumonia in analogy to experiences in severe influenza pneumonia.
T6 691-984 Sentence denotes Both individuals were without typical risk factors for IPA, e.g. steroid medication or other immunospuppression, and were admitted from a secondary-care hospital with pneumonia caused by COVID-19 to our intensive care unit (ICU) after progression to severe acute respiratory distress syndrome.
T7 985-1357 Sentence denotes In the initial bronchoalveolar lavage of both patients only COVID-19 was found (PCR negative for influenza virus and respiratory syncytial virus); a follow-up bronchoalveolar lavage because of ongoing fever a few days later (days 5 and 6 after ICU admission) showed elevated galactomannan and growth of Aspergillus fumigatus in standard culture, suggesting IPA (Table 1 ).
T8 1358-1507 Sentence denotes All patients received a chest computed tomography scan before ICU admittance with typical signs for COVID-19 pneumonia but no specific signs for IPA.
T9 1508-1582 Sentence denotes Follow-up computed tomography scans were not performed for safety reasons.
T10 1583-1671 Sentence denotes Table 1 Results of galactomannan (bronchoalveolar lavage and serum) and standard culture
T11 1672-1770 Sentence denotes Patient 1(80 years, male, suspected pulmonary fibrosis) Patient 2(70 years, male, no risk factors)
T12 1771-1826 Sentence denotes Galactomannan from BAL (ODI; normal range <1.0) 6.3 6.1
T13 1827-1885 Sentence denotes Galactomannan from serum (ODI; normal range <0.5) 1.5 <0.5
T14 1886-1946 Sentence denotes Standard culture Aspergillus fumigatus Aspergillus fumigatus
T15 1947-1990 Sentence denotes SARS-CoV-2 (at follow up) positive positive
T16 1991-2035 Sentence denotes Laboratory parameters, mean at IPA diagnosis
T17 2036-2055 Sentence denotes  CRP (mg/dL) 26 5.1
T18 2056-2076 Sentence denotes  IL-6 (pg/mL) 460 82
T19 2077-2097 Sentence denotes  PCT (ng/mL) 3.7 0.4
T20 2098-2125 Sentence denotes  D-Dimer (μg/L) 4820 14 151
T21 2126-2144 Sentence denotes  LDH (U/L) 481 530
T22 2145-2179 Sentence denotes  Leucocyte count (G/L) 10.38 14.55
T23 2180-2201 Sentence denotes  Lymphocytes (%) 15 7
T24 2202-2223 Sentence denotes Renal failure Yes Yes
T25 2224-2289 Sentence denotes Classical risk factors for invasive pulmonary aspergillosis No No
T26 2290-2494 Sentence denotes Abbreviations: BAL, bronchoalveolar lavage; CRP, C-reactive protein; IL-6, interleukin 6; IPA, invasive pulmonary aspergillosis; LDH, lactate dehydrogenase; ODI, optical density index; PCT, procalcitonin.
T27 2495-2700 Sentence denotes The time-point of IPA diagnosis is in line with previous studies that demonstrated a median time to IPA diagnosis between 3 and 9 days after ICU admission of patients with severe influenza pneumonia [1,3].
T28 2701-2784 Sentence denotes In these patients also, high incidence and mortality rates could be observed [1,3].
T29 2785-2903 Sentence denotes Both patients in our report died as the result of ongoing acute respiratory distress syndrome with multiorgan failure.
T30 2904-3035 Sentence denotes Growth of Aspergillus spp. in a respiratory culture from an ICU patient is often interpreted as colonization rather than infection.
T31 3036-3189 Sentence denotes Other typical diagnostics for IPA, such as biopsy or imaging techniques, may be more challenging in critically ill COVID-19 patients for several reasons.
T32 3190-3362 Sentence denotes Therefore, additional testing of bronchoalveolar lavage specimens for galactomannan is easy, and the specificity of an ODI cut-off of >1·0 is about 90% to detect IPA [4,5].
T33 3363-3453 Sentence denotes Early and sufficient antifungal medication is the cornerstone for effective IPA treatment.
T34 3454-3645 Sentence denotes Our patients were treated with liposomal amphotericin-B (3 mg/kg) because of multiorgan failure including hepatic failure; however, voriconazole and isavuconazole are sufficient alternatives.
T35 3646-3749 Sentence denotes In conclusion, COVID-19-associated IPA may lead to a poor outcome even in immune competent individuals.
T36 3750-3930 Sentence denotes Further studies are needed to indicate if COVID-19-associated invasive pulmonary aspergillosis is a relevant complication in critically ill patients with severe COVID-19 pneumonia.
T37 3932-3957 Sentence denotes Transparency declarations
T38 3958-4072 Sentence denotes None of the authors has any potential financial or non-financial conflicts of interest related to this manuscript.
T39 4073-4165 Sentence denotes None of the authors has received any funding or financial support regarding this manuscript.
T40 4166-4226 Sentence denotes The manuscript has not been submitted or accepted elsewhere.
T41 4227-4293 Sentence denotes All authors fulfil the criteria given in the authorship paragraph.
T42 4294-4390 Sentence denotes No writing assistance other than copy editing was provided in the preparation of the manuscript.
T43 4392-4408 Sentence denotes Research funding
T44 4409-4428 Sentence denotes Nothing to declare.
T45 4430-4454 Sentence denotes Employment or leadership
T46 4455-4474 Sentence denotes Nothing to declare.
T47 4475-4558 Sentence denotes Tobias Lahmer received travel grants from 10.13039/100004319Pfizer, Gilead and MSD.