| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T21 |
0-92 |
Sentence |
denotes |
Coronaviruses have characteristic clove-shape spikes (“corona”) protruding from the surface. |
| T22 |
93-259 |
Sentence |
denotes |
The spikes are protein complexes that virus uses to bind to a receptor (receptor-binding subunit S1) and mediate entry into host cells (a membrane-fusion subunit S2). |
| T23 |
260-388 |
Sentence |
denotes |
Upon binding virus fuses with the human cell membrane, allowing the genome of the virus to enter the cell and begin replication. |
| T24 |
389-583 |
Sentence |
denotes |
The receptor-binding domain of SARS-CoV-2 spikes are closely related to those of SARS-CoVs (73.8–74.9% amino acid identity) and SARS-like CoVs (75.9–76.9% amino acid identity) (Wu et al., 2020). |
| T25 |
584-757 |
Sentence |
denotes |
SARS-CoV-2 uses the human angiotensin I converting enzyme 2 (ACE2) receptor for cell entry (Lu et al., 2020), which could potentially facilitate human-to-human transmission. |
| T26 |
758-916 |
Sentence |
denotes |
In addition to mediating virus entry, the spike feature is a critical determinant of viral host range and tissue tropism and a cause of host immune responses. |
