PMC:7264098 / 25939-27145 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T151 0-255 Sentence denotes Although only a limited number of MSC-based clinical trials have been completed to date, in a small number of COVID-19 patients, the prospects of using these cells in the clinical setting to treat and prevent COVID-19-induced lung damage appear promising.
T152 256-465 Sentence denotes Successfully completed Phase I trials for the treatment of ARDS and emerging promising preliminary results from current trials will soon shed light on the effectiveness of MSCs for the treatment of SARS-CoV-2.
T153 466-633 Sentence denotes The proposed clinical study that aims to deliver MSC-derived exosomes via the inhalation route to COVID-19 patients (NCT04276987) will potentially be a paradigm shift.
T154 634-946 Sentence denotes In the light of a recent study that demonstrated efficacy of inhaled stem cell-derived therapy in both ex vivo and animal models of pulmonary fibrosis (Dinh et al., 2020), the inhalation route due to advantages outlined above, may become more routinely investigated along with the conventional intravenous route.
T155 947-1206 Sentence denotes Importantly, regardless of the route of delivery and type of stem cells, larger-scale clinical trials strictly designed with the placebo arm and patient randomization are necessary to achieve successful stem cell-based therapies for the treatment of COVID-19.