LitCovid-sentences  

PMC:7258756 / 79-2159 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T3 0-24 Sentence denotes Background & objectives:
T4 25-143 Sentence denotes Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has globally affected 195 countries.
T5 144-264 Sentence denotes In India, suspected cases were screened for SARS-CoV-2 as per the advisory of the Ministry of Health and Family Welfare.
T6 265-395 Sentence denotes The objective of this study was to characterize SARS-CoV-2 sequences from three identified positive cases as on February 29, 2020.
T7 397-405 Sentence denotes Methods:
T8 406-635 Sentence denotes Throat swab/nasal swab specimens for a total of 881 suspected cases were screened by E gene and confirmed by RdRp (1), RdRp (2) and N gene real-time reverse transcription-polymerase chain reactions and next-generation sequencing.
T9 636-775 Sentence denotes Phylogenetic analysis, molecular characterization and prediction of B- and T-cell epitopes for Indian SARS-CoV-2 sequences were undertaken.
T10 777-785 Sentence denotes Results:
T11 786-878 Sentence denotes Three cases with a travel history from Wuhan, China, were confirmed positive for SARS-CoV-2.
T12 879-991 Sentence denotes Almost complete (29,851 nucleotides) genomes of case 1, case 3 and a fragmented genome for case 2 were obtained.
T13 992-1151 Sentence denotes The sequences of Indian SARS-CoV-2 though not identical showed high (~99.98%) identity with Wuhan seafood market pneumonia virus (accession number: NC 045512).
T14 1152-1238 Sentence denotes Phylogenetic analysis showed that the Indian sequences belonged to different clusters.
T15 1239-1412 Sentence denotes Predicted linear B-cell epitopes were found to be concentrated in the S1 domain of spike protein, and a conformational epitope was identified in the receptor-binding domain.
T16 1413-1555 Sentence denotes The predicted T-cell epitopes showed broad human leucocyte antigen allele coverage of A and B supertypes predominant in the Indian population.
T17 1557-1586 Sentence denotes Interpretation & conclusions:
T18 1587-1691 Sentence denotes The two SARS-CoV-2 sequences obtained from India represent two different introductions into the country.
T19 1692-1739 Sentence denotes The genetic heterogeneity is as noted globally.
T20 1740-1875 Sentence denotes The identified B- and T-cell epitopes may be considered suitable for future experiments towards the design of vaccines and diagnostics.
T21 1876-2080 Sentence denotes Continuous monitoring and analysis of the sequences of new cases from India and the other affected countries would be vital to understand the genetic evolution and rates of substitution of the SARS-CoV-2.