PMC:7258756 / 17871-18945 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T135 0-20 Sentence denotes Epitope predictions:
T136 21-194 Sentence denotes Thirty one linear B-cell epitopes were predicted by Bepipred in the Indian SARS-CoV-2, of which three were found to have a length of <6 amino acids and hence not considered.
T137 195-324 Sentence denotes Linear epitopes were also predicted using the ABCpred prediction tool, which predicted 47 epitopes based on the threshold of 0.8.
T138 325-403 Sentence denotes Regions common to both the prediction methods (n=17) were identified manually.
T139 404-589 Sentence denotes The 17 epitopes were screened for their antigenicity using the VaxiJen v2.0 tool (http://www.ddg-pharmfac.net/vaxijen/VaxiJen/VaxiJen.html), and nine of these epitopes were shortlisted.
T140 590-720 Sentence denotes These epitopes were further screened for their ability to elicit an IFN-γ response, which was predicted using the IFNepitope tool.
T141 721-901 Sentence denotes Finally, five epitopes, four in the S1 domain and one in the S2 domain, were predicted, which could possibly generate an immune response and suppress the IFN-γ response (Table II).
T142 902-1074 Sentence denotes N-linked glycosylation site prediction revealed that two putative glycosylation sites (with a low value for jury agreement) were present within the epitope stretch 328-344.