| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T24 |
0-250 |
Sentence |
denotes |
Here, we provide global and site-specific analyses of N-linked glycosylation on soluble SARS, MERS and HKU1 CoV S glycoproteins and reveal extensive heterogeneity, ranging from oligomannose-type glycans to highly-processed complex-type glycosylation. |
| T25 |
251-471 |
Sentence |
denotes |
The structural mapping of glycans of trimeric S proteins revealed that some of these glycans contribute to the formation of a cluster of oligomannose-type glycans at specific regions of high glycan density on MERS-CoV S. |
| T26 |
472-666 |
Sentence |
denotes |
Molecular evolution analysis of SARS and MERS S genes also reveals a higher incidence of amino-acid diversity on the exposed surfaces of the S proteins that are not occluded by N-linked glycans. |
| T27 |
667-942 |
Sentence |
denotes |
In addition, we compare the structures of the respective glycan coats of SARS and HIV-1 envelope proteins using cryo-electron microscopy (cryo-EM) and computational modelling, which delineate a sparse glycan shield exhibited on SARS S compared with other viral glycoproteins. |
| T28 |
943-1222 |
Sentence |
denotes |
We therefore undertook a comparative analysis of viral glycan shields from characterized class I fusion proteins to highlight how glycosylation density influences oligomannose-type glycan abundance, and the relationship between effective glycan shields and viral evasion ability. |
| T29 |
1223-1311 |
Sentence |
denotes |
Together, these data underscore the importance of glycosylation in viral immune evasion. |
