| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T168 |
0-171 |
Sentence |
denotes |
Mechanistically, COVID-19 is found to be linked to Angiotensin-Converting Enzyme 2, a membrane-bound aminopeptidase highly expressed in lung, intestinal, and heart tissue. |
| T169 |
172-288 |
Sentence |
denotes |
Beyond being implicated in hypertension and diabetes, ACE-2 further functions as a receptor for coronaviruses [58•]. |
| T170 |
289-470 |
Sentence |
denotes |
COVID-19 translocates into lung parenchyma via damaging epithelial cells, resulting in respiratory symptoms, with symptom severity worsening in patients with cardiovascular disease. |
| T171 |
471-616 |
Sentence |
denotes |
ACE2 secretion is noted to be elevated in CVD patients due to increased reliance on angiotensin-receptor blockers for management of hypertension. |
| T172 |
617-805 |
Sentence |
denotes |
At the receptor level, the receptor-binding domain of SARS-CoV spike protein specifically recognizes ACE2, which contributes to both cross-species and human-to-human transmission [59, 60]. |
| T173 |
806-1017 |
Sentence |
denotes |
Documented variability is demonstrated between various strains of SARS-CoV in terms of binding affinity and viral attachment, which is preserved across both humans and animal models of disease transmission [61]. |
| T174 |
1018-1168 |
Sentence |
denotes |
The preserved domains across MERS/SARS may contribute to the heightened inflammatory response and cytokine milieu that leads to severe pneumonia [62]. |
