| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T91 |
0-252 |
Sentence |
denotes |
Human coronaviruses (HCoV) have been established to infect human astrocytes and microglia in neural cell cultures as well as detection of viral RNA in a study of human brain autopsy samples supporting their neurotropic and neuroinvasive properties [5]. |
| T92 |
253-393 |
Sentence |
denotes |
A case report of SARS-CoV-1 infection with CNS symptoms during the SARS epidemic also isolated the virus within a brain tissue specimen [6]. |
| T93 |
394-773 |
Sentence |
denotes |
Although direct evidence of a neurotropic effect of SARS-Cov-2 has not been reported as yet through either cerebrospinal fluid (CSF) or autopsy studies, the presence of neurological symptoms in patients with COVID-19 disease during this current pandemic, and the similarity between the two strains of human coronaviruses (CoV-1 and CoV-2), makes this mechanism highly suggestive. |
| T94 |
774-1001 |
Sentence |
denotes |
Acute symptomatic seizures may be the result of a possible neurotropic effect of the virus or can be a marker of severity of systemic disease itself since CNS symptoms were found mainly in patients with severe COVID-19 disease. |
| T95 |
1002-1155 |
Sentence |
denotes |
After penetration of the blood–brain barrier, the virus can slow the cerebral microcirculation, possibly through the creation of a hypercoagulable state. |
| T96 |
1156-1269 |
Sentence |
denotes |
This allows increased interaction of SARS-CoV-2 with the endothelial receptors and receptors on glial tissue [7]. |
| T97 |
1270-1380 |
Sentence |
denotes |
The interaction at the glia may predispose patients to seizures as seen in other neurological diseases [8, 9]. |
