LitCovid-sentences  

PMC:7253233 / 104-2647 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE-old TextAE

Id Subject Object Predicate Lexical cue
T4 0-10 Sentence denotes Background
T5 11-83 Sentence denotes The coronavirus disease of 2019 (COVID-19) emerged as a global pandemic.
T6 84-316 Sentence denotes Historically, the group of human coronaviruses can also affect the central nervous system leading to neurological symptoms; however, the causative mechanisms of the neurological manifestations of COVID-19 disease are not well known.
T7 317-447 Sentence denotes Seizures have not been directly reported as a part of COVID-19 outside of patients with previously known brain injury or epilepsy.
T8 448-566 Sentence denotes We report two cases of acute symptomatic seizures, in non-epileptic patients, associated with severe COVID-19 disease.
T9 568-586 Sentence denotes Case Presentations
T10 587-731 Sentence denotes Two advanced-age, non-epileptic, male patients presented to our northeast Ohio-based health system with concern for infection in Mid-March 2020.
T11 732-831 Sentence denotes Both had a history of lung disease and during their hospitalization tested positive for SARS-CoV-2.
T12 832-942 Sentence denotes They developed acute encephalopathy days into their hospitalization with clinical and electrographic seizures.
T13 943-998 Sentence denotes Resolution of seizures was achieved with levetiracetam.
T14 1000-1010 Sentence denotes Discussion
T15 1011-1141 Sentence denotes Patients with COVID-19 disease are at an elevated risk for seizures, and the mechanism of these seizures is likely multifactorial.
T16 1142-1316 Sentence denotes Clinical (motor) seizures may not be readily detected in this population due to the expansive utilization of sedatives and paralytics for respiratory optimization strategies.
T17 1317-1503 Sentence denotes Many of these patients are also not electrographically monitored for seizures due to limited resources, multifactorial risk for acute encephalopathy, and the risk of cross-contamination.
T18 1504-1742 Sentence denotes Previously, several neurological symptoms were seen in patients with more advanced COVID-19 disease, and these were thought to be secondary to multi-system organ failure and/or disseminated intravascular coagulopathy-related brain injury.
T19 1743-1882 Sentence denotes However, these patients may also have an advanced breakdown of the blood–brain barrier precipitated by pro-inflammatory cytokine reactions.
T20 1883-1985 Sentence denotes The neurotropic effect and neuroinvasiveness of SARS-Coronavirus-2 have not been directly established.
T21 1987-1998 Sentence denotes Conclusions
T22 1999-2073 Sentence denotes Acute symptomatic seizures are possible in patients with COVID-19 disease.
T23 2074-2265 Sentence denotes These seizures are likely multifactorial in origin, including cortical irritation due to blood–brain barrier breakdown, precipitated by the cytokine reaction as a part of the viral infection.
T24 2266-2436 Sentence denotes Patients with clinical signs of seizures or otherwise unexplained encephalopathy may benefit from electroencephalography monitoring and/or empiric anti-epileptic therapy.
T25 2437-2543 Sentence denotes Further studies are needed to elucidate the risk of seizures and benefit of monitoring in this population.