| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T450 |
0-353 |
Sentence |
denotes |
Altogether, we anticipate that comprehensive characterization of the putative cellular targets of SARS-CoV-2 will be critical to understand basic mechanisms of viral tropism and disease pathophysiology, inform differential susceptibility among vulnerable populations, and potentially suggest unanticipated targets for drug inhibitors of viral infection. |
| T451 |
354-491 |
Sentence |
denotes |
The cellular targets we nominate will need to be confirmed by specific reagents for SARS-CoV-2, as done for SARS-CoV (Ding et al., 2004). |
| T452 |
492-665 |
Sentence |
denotes |
Furthermore, the transcriptional response to the virus will need to be rigorously characterized in appropriate in vitro and in vivo model systems (Blanco-Melo et al., 2020). |
| T453 |
666-810 |
Sentence |
denotes |
We provide gene lists associated with target cells in specific tissues and diseases to aid the community in understanding this emergent disease. |
| T454 |
811-990 |
Sentence |
denotes |
A concurrent HCA Lung Biological Network study assessing ACE2 and TMPRSS2 across more tissues also identified enrichment in nasal goblet and ciliated cells (Sungnak et al., 2020). |
| T455 |
991-1193 |
Sentence |
denotes |
Other studies are considering additional tissues; co-variates such as age, sex, and co-infection state; and represent a large coordinated international effort to the ongoing crisis (Pinto et al., 2020). |
| T456 |
1194-1477 |
Sentence |
denotes |
One study in particular identified upregulation of ACE2 by respiratory viruses and TMPRSS2 by IL-13 in a pediatric cohort, suggesting further links to how underlying allergic conditions or co-infections might modulate these two SARS-CoV-2-related host factors (Sajuthi et al., 2020). |
