LitCovid-sentences  

PMC:7252096 / 59156-62133 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T394 96-100 Sentence denotes (A).
T395 101-323 Sentence denotes Probability of capturing and transcribing at least 1 ACE2 cDNA molecule, as a function of the capture/reverse transcription efficiency for a single molecule and the number of ACE2 molecules expressed in an individual cell.
T396 324-554 Sentence denotes Note that Drop-Seq provides a capture/transcription efficiency of approximately 11-13%, setting a floor on this parameter, and the experimental platforms used in this study are either equivalent or superior (Macosko et al., 2015).
T397 555-559 Sentence denotes (B).
T398 560-764 Sentence denotes Distribution of ACE2 fractional abundance within individual cells’ cDNA libraries (i.e., ACE2 UMIs / total number of reads), across non-human primate lung and ileum cell populations (see Figures 1 and 3).
T399 765-883 Sentence denotes Mean fractional abundance among ACE2+ lung cells = 5.0E-5; mean fractional abundance among ACE2+ ileum cells = 2.7E-4.
T400 884-888 Sentence denotes (C).
T401 889-1004 Sentence denotes Distribution of the number of reads within non-human primate lung and ileum cell populations (see Figures 1 and 3).
T402 1005-1159 Sentence denotes Mean ± SEM reads among all lung cells = 28,512 ± 344; ACE2+ lung cells = 28,553 ± 2,988; all ileum cells = 14,864 ± 288; ACE2+ ileum cells = 10,591 ± 441.
T403 1160-1164 Sentence denotes (D).
T404 1165-1409 Sentence denotes Probability of observing at least one transcript for a gene of interest (e.g., ACE2) within an individual cell, as a function of sequencing depth and the gene’s fractional abundance (i.e., ACE2 reads / all reads) within the cell’s cDNA library.
T405 1410-1695 Sentence denotes Fractional abundance provides the probability that a single read corresponds to the gene of interest, and presented heatmap indicates the probability that at least one read in the total number of reads allocated to the cell (i.e., from 103 to 106) originates from the gene of interest.
T406 1696-1872 Sentence denotes Mean read depths and ACE2 fractional abundances for each tissue produce a 93.7% probability of detecting at least 1 ACE2 read in ileum cells, and a 76.0% chance for lung cells.
T407 1873-1988 Sentence denotes Outlined rectangles highlight the regimes where cells from lung (turquoise) and ileum (pink) samples typically lie.
T408 1989-1993 Sentence denotes (E).
T409 1994-2103 Sentence denotes Number of ACE2+ cells within each cluster, as a function of average read depth for all cells in that cluster.
T410 2104-2259 Sentence denotes Number of cells detected as ACE2+ is not correlated with read depth, even across relatively wide ranges of average read depths (Pearson’s r = −0.31, n.s.).
T411 2260-2264 Sentence denotes (F).
T412 2265-2417 Sentence denotes Probability of observing a particular number of cells positive for a gene of interest within a cluster, as a function of number of cells in the cluster.
T413 2418-2606 Sentence denotes Probabilities were calculated under a negative binomial distribution with parameter p = 0.063 (the proportion of ACE2+ cells among type II pneumocytes presented in Figure 1; STAR Methods).
T414 2607-2682 Sentence denotes The horizontal gray line indicates the arbitrary cut-off value of p = 0.05.
T415 2683-2687 Sentence denotes (G).
T416 2688-2977 Sentence denotes Given a population of cells with a known proportion that are positive for a gene of interest, probability of observing no positive cells (i.e., false negative identification of the cluster; solid lines) and probability of observing at least one positive cell as a function of cluster size.