| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T82 |
0-49 |
Sentence |
denotes |
7 Strategy for investigating allo/autoantibodies |
| T83 |
50-276 |
Sentence |
denotes |
We are convinced that this hypothesis could be easily explored by testing allo-antibodies to ACE-2, or to its complexes with SARS-CoV-2 S Protein or its cleaved subunits, S1, and eventually associated with S2 or nucleoprotein. |
| T84 |
277-478 |
Sentence |
denotes |
ACE-2 is now available in the recombinant form, even if still very expensive, and recombinant SARS-CoV-2 proteins or peptide sequences, including S Protein and S1, are available from various suppliers. |
| T85 |
479-773 |
Sentence |
denotes |
A capture ELISA, designed by coating recombinant ACE-2, or its complexes with S-Protein or its S1 subunit, or eventually the viral nucleoprotein, onto the plate could be designed for capturing possible antibodies present in Covid-19 patients, especially those with delayed severe complications. |
| T86 |
774-868 |
Sentence |
denotes |
Binding of antibody to these components, in the presence or absence of ACE-2 must be compared. |
| T87 |
869-1045 |
Sentence |
denotes |
This approach can allow the measurement amount of the kinetic course of these antibodies during the pathological evolution, and eventually in patients following their recovery. |
| T88 |
1046-1188 |
Sentence |
denotes |
If present, these antibodies are expected to be alloantibodies, as induced by the association of a viral protein with a body’s self-component. |
| T89 |
1189-1340 |
Sentence |
denotes |
However, if immuno stimulation is first induced by neo-epitopes exposed on ACE-2 when complexed with S Protein or S1, the response could be autoimmune. |
| T90 |
1341-1400 |
Sentence |
denotes |
Laboratory investigations can clarify these considerations. |
