| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T12 |
0-158 |
Sentence |
denotes |
Fast and extended knowledge is becoming available on the new viral disease that emerged in December 2019, causing enormous challenges at international levels. |
| T13 |
159-552 |
Sentence |
denotes |
The pathology of this obscure virus, named Severe Acute Respiratory Syndrome - Coronavirus-2 (SARS-CoV-2), is characterized by many patients remaining asymptomatic or with only benign symptoms, but this disease becomes life-threatening in some patients and requires hospitalization in intensive care units or resuscitation [1,2], and is often with a fatal outcome, yet to be fully established. |
| T14 |
553-771 |
Sentence |
denotes |
Activation of the hemostasis system has been observed in many patients with severe complications, with occurrence of disseminated intravascular coagulopathy (DIC) or pulmonary embolism (PE), and multiorgan failure [3]. |
| T15 |
772-875 |
Sentence |
denotes |
DDimer is frequently elevated, and the disease prognosis worsens with its increasing concentration [2]. |
| T16 |
876-917 |
Sentence |
denotes |
Sepsis can also be present in some cases. |
| T17 |
918-1036 |
Sentence |
denotes |
Anticoagulant therapy, especially with LMWH, can improve the disease evolution and reduce the lethality incidence [4]. |
| T18 |
1037-1335 |
Sentence |
denotes |
In addition, many patients with severe complications face a sudden worsening, starting 7 to > 14 days after the preliminary symptoms, although the immune response is effective with the presence of IgG and/or IgMs and is expected to fight the disease by controlling its pathological evolution [5,6]. |
| T19 |
1336-1466 |
Sentence |
denotes |
This worsening is associated with an exacerbated immunological activity, a strong inflammatory response, and a cytokine storm [7]. |
| T20 |
1467-1576 |
Sentence |
denotes |
New therapeutic approaches rely on controlling the pro-inflammatory cytokines, mainly IL-6, IL-10, and TNF-α. |
| T21 |
1577-1787 |
Sentence |
denotes |
Lastly, there is a strong association of disease severity with age and presence of comorbidities, mainly hypertension, diabetes, obesity, chronic obstructive pulmonary disease and cardiovascular diseases (CVD). |
| T22 |
1788-1882 |
Sentence |
denotes |
However, complications can also occur in younger persons without any known risk factors [1,2]. |
