LitCovid-sentences  

PMC:7247521 / 37275-40378 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T275 0-99 Sentence denotes 3.8 Validation of drug positioning for QFPD against COVID-19 via the robustness of disease network
T276 100-234 Sentence denotes Firstly, the robustness of whole networks against formula attack was assessed to evaluate QFPD attack on the COVID-19 disease network.
T277 235-513 Sentence denotes Interestingly, Table 4 and Fig. 11 showed that MSXG, SGMH, XCH, WLS and Others attack on the COVID-19 network were characterized by greater disturbance score than negative control (BXTM), and increasing dependence on hub nodes, indicating greater fragility under formula attack.
T278 514-625 Sentence denotes In addition, SGMH, MSXG, and Others exerted higher disturbance score than the positive control (YDBF) Table 5 .
T279 626-717 Sentence denotes Fig. 11 Evaluation of the effect of QFPD on the robustness disturbance of COVID-19 network.
T280 718-823 Sentence denotes Blue normal distribution: drug attack on random networks as a null distribution for the permutation test.
T281 824-904 Sentence denotes Red vertical line: the disturbance rate of the drug to the real disease network.
T282 905-982 Sentence denotes Fist row: MXSG, second row: SGMH, third row: XCH, fourth row: WLS, fifth row:
T283 983-990 Sentence denotes Others.
T284 991-1269 Sentence denotes Fist column: average connectivity, second row: average length of shortest path, third row: connection centrality, fourth row: closeness centrality. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
T285 1270-1350 Sentence denotes Table 5 Docking score between common ingredients of QFPD and 2019-nCov proteins.
T286 1351-1398 Sentence denotes Molecule MS1 MX16 MX17 MX8 MXO1 SO1 SX1 WO1 XO1
T287 1399-1455 Sentence denotes Main Protease −7.6 −7 −7.8 −7.8 −7.8 −7.2 −7.1 −7.4 −7.4
T288 1456-1519 Sentence denotes Papain-like protease −8 −8.2 −8.1 −8.1 −8.2 −8.2 −9.2 −8.7 −8.3
T289 1520-1574 Sentence denotes RdRp with RNA −8.6 −8 −7.9 −7.9 −8 −8.4 −8.2 −8.8 −9.5
T290 1575-1634 Sentence denotes RdRp without RNA −7.1 −6.8 −6.8 −6.8 −7 −7.1 −6.9 −7.5 −7.1
T291 1635-1697 Sentence denotes Helicase ADP site −6.2 −6.5 −6.3 −6.1 −6.2 −6.4 −6.8 −6.2 −6.8
T292 1698-1760 Sentence denotes Helicase NCB site −7.4 −7.1 −7.2 −7.2 −7.5 −7.5 −7.4 −7.6 −7.5
T293 1761-1815 Sentence denotes Nsp14(ExoN) −7.2 −6.6 −6.6 −6.7 −6.9 −7 −6.9 −7.1 −7.1
T294 1816-1876 Sentence denotes Nsp14(N7-MTase) −8.6 −8.3 −8.4 −8.3 −8.6 −8.3 −9.4 −8.7 −8.7
T295 1877-1945 Sentence denotes Nsp15(endoribonuclease) −6.2 −6.8 −6.4 −6.4 −6.3 −6.5 −6.8 −6.4 −6.6
T296 1946-2008 Sentence denotes Nsp16(2′-O-MTase) −8.1 −7.4 −7.6 −7.8 −7.8 −8.3 −7.7 −8.4 −8.2
T297 2009-2068 Sentence denotes N protein NCB site −8.1 −7.9 −8 −8 −7.6 −7.8 −7.5 −7.7 −7.9
T298 2069-2136 Sentence denotes E protein(ion channel) −6.4 −6.9 −7.2 −7.2 −6.9 −6.9 −7.9 −6.8 −6.8
T299 2137-2165 Sentence denotes M: MXSG, S: SGMH, X: XCH, O:
T300 2166-2173 Sentence denotes Others.
T301 2174-2308 Sentence denotes Next, to illustrate the mechanism of QFPD against COVID-19, a formula-attacked target-KEGG pathway network was constructed (Fig. 12 ).
T302 2309-2662 Sentence denotes This network showed that MSXG, SGMH, XCH, WLS and Others interacted with 8 drug-attacked nodes (Cdc20, Ido1, Ifng, Il10, Il6, Ptger4, Spi1, Tnf), and 24 drug-attacked nodes in the COVID-19 network were related to Graft-versus-host disease, cytokine-cytokine receptor interaction, asthma, influenza A, inflammatory bowel disease, JAK-STAT signaling, etc.
T303 2663-2721 Sentence denotes Fig. 12 Disturbance analysis of QFPD for COVID-19 network.
T304 2722-2724 Sentence denotes A:
T305 2725-2777 Sentence denotes Venn diagram of the five formulae’ attacked targets.
T306 2778-2780 Sentence denotes B:
T307 2781-2909 Sentence denotes Formula-attacked target-KEGG pathway network; green square: formula, yellow diamond: attacked target, red circle: KEGG pathways.
T308 2910-3103 Sentence denotes The bigger the size of the nodes is, the higher the degree is. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)