LitCovid-sentences  

PMC:7247521 / 27354-28994 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T196 0-179 Sentence denotes Regarding the absorption parameters, all 20 compounds (Table 2 ) presented a promising oral availability including the optimal Caco-2 cell permeability, HIA and skin permeability.
T197 180-411 Sentence denotes The drug distribution results showed that most of the compounds distributed in tissue (VDss> 0.45: tissue, VDss <−0.15: plasma) with good unbound fraction scores, thus becoming available to interact with the pharmacological target.
T198 412-534 Sentence denotes Only compound W5 and W11 were entirely unable to penetrate the blood-brain barrier (BBB) and central nervous system (CNS).
T199 535-669 Sentence denotes In addition, 15 compounds presented a good renal elimination and were not substrates of the renal organic cation transporter 2 (OCT2).
T200 670-925 Sentence denotes Finally, 14 compounds did not present any particular toxicity problems including AMES toxicity, maximum tolerated dose, hERG I inhibitor, hERG II inhibitor, oral rat acute toxicity (LD50), hepatotoxicity, skin sensitisation, and minnow toxicity (Fig. 7B).
T201 926-974 Sentence denotes Table 2 20 potential active compounds from QFPD.
T202 975-1040 Sentence denotes Pubchem Molecular Name Structure Pubchem Molecular Name Structure
T203 1041-1101 Sentence denotes CID6918970 M3 ZINC5356864 CID10019512 S5 3-O-Methylviolanone
T204 1102-1147 Sentence denotes CID336327 M5 Medicarpin CID9064 W5 Cianidanol
T205 1148-1194 Sentence denotes CID14057197 O1 – CID182232 W11 (+)-Epicatechin
T206 1195-1251 Sentence denotes CID42607889 O2 Alysifolinone CID25721350 X1 ZINC13130930
T207 1252-1309 Sentence denotes CID3902 S1 letrozole CID14135323 X2 (2S)-dihydrobaicalein
T208 1310-1359 Sentence denotes CID821279 X4 ZINC338038 CID439246 MXO1 naringenin
T209 1360-1419 Sentence denotes CID440833 MS1 Leucocyanidol CID676152 SO1 SR-01,000,767,148
T210 1420-1482 Sentence denotes CID177149 MX16 (+)-Vestitol CID11438306 SX1 cyclo(L-Tyr-l-Phe)
T211 1483-1540 Sentence denotes CID114829 MX17 Liquiritigenin CID712316 WO1 (-)-taxifolin
T212 1541-1603 Sentence denotes CID928837 MX8 ZINC519174 CID373261 XO1 Eriodyctiol (flavanone)
T213 1604-1632 Sentence denotes M: MXSG, S: SGMH, X: XCH, O:
T214 1633-1640 Sentence denotes Others.