LitCovid-sentences  

PMC:7247521 / 20558-23971 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T118 0-59 Sentence denotes 3.3 Construction of PPI network and MCODE modules analysis
T119 60-225 Sentence denotes To further explore the functional relationship among five formulae, PPI networks were constructed through Metascape, and visual composition carried out by Cytoscape.
T120 226-431 Sentence denotes Firstly, the potential 192 target genes of MXSG were analyzed by PPI network, and the results showed that there were 144 nodes and 510 edges, which represented the interaction between protein and function.
T121 432-576 Sentence denotes The MXSG PPI network function module was confirmed by the MCODE plug-in and a list of the corresponding meaningful modules presented (Fig. 5 A).
T122 577-605 Sentence denotes 3 modules scores were > 2.5.
T123 606-622 Sentence denotes Module 1 (score:
T124 623-698 Sentence denotes 5.769) consisted of 13 nodes and the seed gene was COX7A1; Module 2 (score:
T125 699-775 Sentence denotes 4.429) consisted of 14 nodes and the seed gene was ALDH1A1; module 3 (score:
T126 776-830 Sentence denotes 5.0) consisted of 11 nodes and the seed gene was CNR2.
T127 831-1030 Sentence denotes KEGG pathway enrichment analysis showed that MXSG modules were enriched in neuroactive ligand-receptor interaction, calcium signaling pathway, inflammatory mediator regulation of TRP channels, et.al.
T128 1031-1069 Sentence denotes Fig. 5 KEGG analysis of MCODE modules.
T129 1070-1212 Sentence denotes MCODE analysis was performed after the construction of the five formulae’ targets PPI; then, KEGG analysis was conducted on the MCODE modules.
T130 1213-1224 Sentence denotes A: MXSG, B:
T131 1225-1257 Sentence denotes Others, C: WLS, D: SGMH, E: XCH.
T132 1258-1400 Sentence denotes Secondly, the potential 99 target genes of Others were analyzed by PPI network, and the results showed that there were 77 nodes and 194 edges.
T133 1401-1442 Sentence denotes Only 1 module score were > 2.5 (Fig. 5B).
T134 1443-1459 Sentence denotes Module 1 (score:
T135 1460-1518 Sentence denotes 5.769) consisted of 13 nodes and the seed gene was COX7A1.
T136 1519-1679 Sentence denotes KEGG pathway enrichment analysis showed that Others modules were enriched in huntington's disease, glycolysis / gluconeogenesis, Notch signaling pathway, et.al.
T137 1680-1818 Sentence denotes Thirdly, the potential 96 target genes of WLS were analyzed by PPI network, and the results showed that there were 60 nodes and 143 edges.
T138 1819-1861 Sentence denotes Only 1 modules score were > 2.5 (Fig. 5C).
T139 1862-1878 Sentence denotes Module 1 (score:
T140 1879-1935 Sentence denotes 2.706) consisted of 17 nodes and the seed gene was CNR2.
T141 1936-2125 Sentence denotes KEGG pathway enrichment analysis showed that WLS modules were enriched in thyroid hormone signaling pathway, adipocytokine signaling pathway, neuroactive ligand-receptor interaction, et.al.
T142 2126-2268 Sentence denotes Fourthly, the potential 201 target genes of SGMH were analyzed by PPI network, and the results showed that there were 153 nodes and 505 edges.
T143 2269-2307 Sentence denotes 3 modules scores were > 2.5 (Fig. 5D).
T144 2308-2324 Sentence denotes Module 1 (score:
T145 2325-2399 Sentence denotes 3.529) consisted of 17 nodes and the seed gene was ACSS1; Module 2 (score:
T146 2400-2470 Sentence denotes 4.5) consisted of 7 nodes and the seed gene was CNR2; module 3 (score:
T147 2471-2525 Sentence denotes 3.5) consisted of 8 nodes and the seed gene was PRKCG.
T148 2526-2687 Sentence denotes KEGG pathway enrichment analysis showed that SGMH modules were enriched in insulin resistance, adipocytokine signaling pathway, Th17 cell differentiation, et.al.
T149 2688-2828 Sentence denotes At last, the potential 221 target genes of XCH were analyzed by PPI network, and the results showed that there were 166 nodes and 643 edges.
T150 2829-2867 Sentence denotes 5 modules scores were > 2.5 (Fig. 5E).
T151 2868-2884 Sentence denotes Module 1 (score:
T152 2885-2960 Sentence denotes 5.769) consisted of 13 nodes and the seed gene was COX7A1; Module 2 (score:
T153 2961-3034 Sentence denotes 2.769) consisted of 13 nodes and the seed gene was RRM1; module 3 (score:
T154 3035-3106 Sentence denotes 5.5) consisted of 12 nodes and the seed gene was CNR2; module 4 (score:
T155 3107-3181 Sentence denotes 2.909) consisted of 11 nodes and the seed gene was ACSS1; module 5 (score:
T156 3182-3236 Sentence denotes 3.0) consisted of 7 nodes and the seed gene was FFAR1.
T157 3237-3413 Sentence denotes KEGG pathway enrichment analysis showed that XCH modules were enriched in calcium signaling pathway, cGMP-PKG signaling pathway, neuroactive ligand-receptor interaction, et.al.