LitCovid-sentences  

PMC:7243778 / 25861-30465 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T201 0-63 Sentence denotes 6.1 Effect of cross-reactive antibodies on SARS-CoV-2 pandemic
T202 64-230 Sentence denotes Due to the high similarity of S proteins from SARS-CoV and MERS-CoV [73], their specific cross-nAbs were tested against SARS-CoV-2 infection in the COVID-19 outbreak.
T203 231-375 Sentence denotes Serum Abs from recovered SARS-CoV patients could efficiently cross-neutralize SARS-CoV-2 but with lower efficiency as compared to SARS-CoV [92].
T204 376-459 Sentence denotes Cross-reactive Abs against SARS-CoV-2 S protein mostly target non-RBD regions [93].
T205 460-635 Sentence denotes Using simulation technique, the binding of five Abs against SARS-CoV, six Abs anti-MERS-CoV to RBD of SARS-CoV-2 was predicted with Rosetta antibody-antigen docking protocols.
T206 636-749 Sentence denotes The amino acid position 445–449 (VGGNY) and 470–486 (TEIYQAGSTPCNGVEGF) were found to be conserved in SARS-CoV-2.
T207 750-918 Sentence denotes Moreover, in addition to the amino acid positions 71–77 (GTNGTKR) in the NTD region of the S protein, aa 445–449 and 470–486 are potential for further development [94].
T208 919-1011 Sentence denotes The difference between RBD of SARS-CoV and SARS-CoV-2 is located at the C-terminus residues.
T209 1012-1080 Sentence denotes This change has an important impact on the cross-reactivity of nAbs.
T210 1081-1161 Sentence denotes This difference was observed using bioinformatic approaches of epitope analysis.
T211 1162-1227 Sentence denotes The antibody epitope score of SARS-CoV-2 is higher than SARS-CoV.
T212 1228-1431 Sentence denotes Moreover, compared with the conserved regions, the non-conserved regions had a significantly higher antibody epitope score indicating that non-conserved regions of spike proteins are much more antigenic.
T213 1432-1613 Sentence denotes The non-conserved regions also showed significantly higher surface epitope accessibility scores suggesting an easier accessibility for antibody recognition of non-conserved regions.
T214 1614-1704 Sentence denotes The divergence of spike proteins is considered as a major change in the antibody epitopes.
T215 1705-1799 Sentence denotes The search for SARS-CoV-2 requires more effort than simply screening SARS-CoV antibodies [95].
T216 1800-1851 Sentence denotes Antibody response to RBD is viral species-specific.
T217 1852-1986 Sentence denotes Effectively, none of the found SARS-CoV-2 antibodies nor the infected plasma cross-reacted with RBDs from either SARS-CoV or MERS-CoV.
T218 1987-2090 Sentence denotes In a study, 206 monoclonal antibodies specific to the RBD SARS-CoV-2 were identified in eight patients.
T219 2091-2243 Sentence denotes These mAbs are different in: antibody heavy and light chains, antibody clones, CDR3 length… which lead to different binding and neutralizing capacities.
T220 2244-2335 Sentence denotes ACE2 is out-competed with almost 100% efficacity by some mAbs such as P2B-2F6 and P2C-1F11.
T221 2336-2499 Sentence denotes Interestingly the latter and a moderate antibody P2C-1C10 seems to target the different epitopes, and they could be combined for synergistic antiviral effect [96].
T222 2500-2667 Sentence denotes CR3022, a SARS-CoV RBD-specific antibody, can bind strongly with a kd of 6.3 nM to an epitope on RBD that does not overlap with the SARS-Cov-2 ACE-2 binding site [34].
T223 2668-2740 Sentence denotes Despite its strong binding, CR3022 could not neutralize SARS-CoV-2 [97].
T224 2741-2798 Sentence denotes S1 is a specific antigen for SARS-CoV-2 diagnostics [98].
T225 2799-2878 Sentence denotes The S1 subunit of SARS-CoV or SARS-CoV-2 has four core domains S1A through S1D.
T226 2879-3139 Sentence denotes The human 47D11 antibody binds the S1B of both viruses, without competing with S1B binding to ACE2 receptor expressed at the cell surface, and showed cross-neutralizing activity by an unknown mechanism that is different from receptor binding interference [99].
T227 3140-3263 Sentence denotes An immunogenic domain in the S2 subunit of SARS-CoV S (aa 1029–1192) was highly conserved in several strains of SARS-CoV-2.
T228 3264-3410 Sentence denotes Four murine monoclonal Abs, 1A9, 1G10, 2B2 and 4B12, against this S2 subunit of SARS-CoV can also cross-reactive with the S protein of SARS-CoV-2.
T229 3411-3578 Sentence denotes Interestingly, 1A9 can strongly bind the S2 subunit of SARS-CoV-2 through a novel epitope (aa 1111–1130) and can detect S protein in SARS-CoV-2 during infection [100].
T230 3579-3710 Sentence denotes This epitope also overlaps with one of two cytotoxic T-lymphocyte epitopes (aa 884–891 and 1116–1123) of SARS-CoV S2 subunit [101].
T231 3711-3823 Sentence denotes 1A9 is therefore suggested to induce both humoral and cellular immune responses against SARS-CoV and SARS-CoV-2.
T232 3824-4053 Sentence denotes In a serologic cross-reactivity test, Khan et al. found out that 4 out of 5 showed high IgG seroreactivity across the 4 common human coronaviruses but all showed low IgG seroreactivity to SARS-CoV-2, SARS-CoV, and MERS-CoV [102].
T233 4054-4257 Sentence denotes The weak cross-immunity against SARS-CoV-2 from others betacoronaviruses, such as HCoV-OC43 and HCoV-HKU1, could restraint the transmission of SARS-CoV-2 but a resurgence is possible in the future [103].
T234 4258-4412 Sentence denotes Moreover, spike- and non-spike specific CD4+ T cell responses were detectable not only in SARS-CoV-2 infected patients but also in uninfected individuals.
T235 4413-4604 Sentence denotes If there is an absence of antibody cross-reactivity, T lymphocyte cross-reactivity present in 50% of cases will be responsible for the epidemiological evolution of SARS-CoV-2 infection [104].