PMC:7243778 / 23961-25859 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T185 0-213 Sentence denotes SARS-CoV-2 nAbs could be detected in patients from 10 to 15 days after symptoms onset and the positive rate for IgG reached close to 100% around 20 days [81,82] with the highest level during day 31–40 since onset.
T186 214-307 Sentence denotes Some patients (5.7%) had neutralizing Abs titers under the detectable level (ID50: <40) [83].
T187 308-398 Sentence denotes The level of IgG antibodies was different between gender, age and clinical classification.
T188 399-487 Sentence denotes The average IgG antibody level in female patients was higher than in male patients [84].
T189 488-591 Sentence denotes Patient over 40 years old developed higher levels of SARS-CoV-2 specific nAbs than the younger persons.
T190 592-671 Sentence denotes Patients with a worse clinical classification had a higher antibody titer [83].
T191 672-751 Sentence denotes This remark is useful to select a research candidate and to save research time.
T192 752-888 Sentence denotes The passive antibody therapy, such as plasma fusion containing polyclonal antibodies from COVID-19 neutralized patients has been tested.
T193 889-1016 Sentence denotes This method was tested as an option to treat other viruses such as influenza, Ebola or SARS-CoV [[85], [86], [87], [88], [89]].
T194 1017-1127 Sentence denotes The lack of human sera, and the possibility of contamination with other infectious agents limit this strategy.
T195 1128-1233 Sentence denotes However, several groups have reported some positive results demonstrating the potential of this approach.
T196 1234-1434 Sentence denotes After one dose of 200 mL of convalescent plasma derived from recently recovered donors with the neutralizing antibody titers above 1:640, the patients with SARS-CoV-2 positive revealed an improvement.
T197 1435-1512 Sentence denotes Among ten patients, seven patients were virus-negative post transfusion [90].
T198 1513-1692 Sentence denotes Whereas in another study, among 5 patients received transfusion with convalescent plasma with a neutralization titer >40, 3 have been discharged from the hospital (length of stay:
T199 1693-1779 Sentence denotes 53, 51, and 55 days), and 2 are in stable condition at 37 days after transfusion [91].
T200 1780-1898 Sentence denotes More studies might brighter this approach but evaluation in clinical trials are also still far from a bold conclusion.