LitCovid-sentences  

PMC:7243778 / 15906-17976 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T123 0-23 Sentence denotes 4.2 Anti-S2 antibodies
T124 24-202 Sentence denotes In contrast to RBD, the fusion domains are more difficult to access due to the tight folding of viral glycoproteins or the excessively transient exposure during the fusion stage.
T125 203-263 Sentence denotes This is why few epitopes are described in these regions [6].
T126 264-432 Sentence denotes Interestingly, the S2 specific mAbs can neutralize pseudotyped viruses which expressing different S proteins containing RBD sequences of various clinical isolates [47].
T127 433-468 Sentence denotes The S2 protein is highly conserved.
T128 469-596 Sentence denotes No mutation in HR1 was reported in an analysis of the amino acid sequences of the S protein from 94 SARS-CoV clinical isolates.
T129 597-700 Sentence denotes Only few mutations in HR2, at amino acids K1163 or Q1183 for example, were observed in this study [47].
T130 701-746 Sentence denotes Some S2 epitopes inducing nAbs were reported.
T131 747-819 Sentence denotes A peptide containing aa 1055–1192 can elicit neutralizing activity [48].
T132 820-1041 Sentence denotes Two other proteins Trx-F3 and Trx-F9 containing linear antigenic determinants (Leu 803 to Ala 828 and Pro 1061 to Ser 1093, respectively) on the S2 domain were identified by using sera from convalescent SARS-CoV patients.
T133 1042-1099 Sentence denotes Trx-F3 was capable of inducing nAbs in some animals [49].
T134 1100-1272 Sentence denotes Some human mAbs anti-HR1 (1F8, 1D12, 2A12, 2B12, 4A4, 4F9, 5C3, 6C9, 6H2) and anti-HR2 (1E10, 2D2, 2D6, 3A11, 3E10, 3H11, 5B9, 5B10, 5D7, 5E9, 5G8, 5G9, 6H1) were reported.
T135 1273-1462 Sentence denotes With these Abs, the authors showed that the combination of HmAbs targeting different regions of the S protein would likely increase the broad neutralization against different isolates [47].
T136 1463-1562 Sentence denotes A human scFv antibody, named B1, showed a high affinity to an epitope (aa 1023–1189) on S2 protein.
T137 1563-1651 Sentence denotes This antibody also showed potent neutralizing activities against SARS-CoV in vitro [50].
T138 1652-1754 Sentence denotes B1, 1F8 and 5E9 nAbs against epitopes on SARS-CoV S2 also showed effectiveness in neutralization [51].
T139 1755-1849 Sentence denotes The protective immunity by the time in patients after SARS-CoV natural infection was observed.
T140 1850-1965 Sentence denotes After 6 years, the humoral immunity continuously decreased and eventually disappeared in most infected individuals.
T141 1966-2070 Sentence denotes The IgG Ab could be an indicator of neutralizing Ab for the humoral response to SARS-CoV infection [52].