LitCovid-sentences  

PMC:7243768 / 65179-67167 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T482 0-41 Sentence denotes 7.2 SARS-CoV-2 and soluble ACE2 receptor
T483 42-152 Sentence denotes ACE2 is required for the degradation of Ang II to Ang (1–7), reducing the blood pressure through vasodilation.
T484 153-334 Sentence denotes ACE2 exists as both membranous forms, which are found to be anchored to the plasma membrane and the soluble form, circulating in the bloodstream but at a lower proportion [151,152].
T485 335-481 Sentence denotes Besides serving as an entry point for SARS-CoV-2, the higher levels of ACE2 are required by the hypertension patient to reduce the blood pressure.
T486 482-574 Sentence denotes Therefore, the ACE2 levels need to be maintained besides inhibiting the entry of SARS-CoV-2.
T487 575-920 Sentence denotes Thus, the usage of human recombinant soluble ACE2 (hrsACE2) which exhibited positive results in the phase I and phased II clinical trials to elevate the soluble form of ACE2that competes with the membranous ACE2 for binding with SARS-CoV-2 and inhibits the viral entry and replication can be considered as a therapeutic option to treat COVID-19.
T488 921-1039 Sentence denotes Besides inhibiting the viral entry, it also sustains the ACE2 levels required for the degradation of Ang II [153,154].
T489 1040-1107 Sentence denotes Currently, hrsACE2 has been approved as a treatment option of ARDS.
T490 1108-1213 Sentence denotes African green monkey kidney derived cell line; namely, Vero E6 was cultured and infected with SARS-CoV-2.
T491 1214-1312 Sentence denotes Then the infected culture was added with hrsACE2 to estimate the therapeutic potential of hrsACE2.
T492 1313-1462 Sentence denotes 15 h post-infection, the viral replication was found to be inhibited in a dose-dependent manner with reference to the concentration of hrsACE2 added.
T493 1463-1693 Sentence denotes The addition of hrsACE2 to the embryonic stem cells derived kidney organoids comprised of proximal tubular cells and podocytes clusters infected with SARS-CoV-2 had shown to reduce the viral replication in a dose-dependent manner.
T494 1694-1821 Sentence denotes No studies support the in-vivo and the therapeutic roles of hrsACE2 on the pulmonary cells upon SARS-CoV-2 infection [153,155].
T495 1822-1988 Sentence denotes Therefore, the usage of hrsACE2 can be a potential therapeutic option to inhibit the viral infection besides preserving the ACE2 levels and blood pressure in control.