LitCovid-sentences  

PMC:7243768 / 62154-63897 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T447 0-141 Sentence denotes Table 2 Elucidating various drugs used to treat SARS-CoV, MERS-CoV, and SARS-CoV-2, along with their mechanism of action and adverse effects.
T448 142-148 Sentence denotes S. no.
T449 149-218 Sentence denotes Drug Effective against Mechanism of action Adverse effects References
T450 219-221 Sentence denotes 1.
T451 222-408 Sentence denotes Ribavirin SARS-CoV Anti-viral nucleoside analog – inhibits the viral genomic replication Anemia, hypocalcemia, hypomagnesemia, developed the risk of teratogenicity and bradycardia [118].
T452 409-411 Sentence denotes 2.
T453 412-493 Sentence denotes Lopinavir SARS-CoV Protease inhibitors Diarrhea, nausea, vomiting, headache [122]
T454 494-496 Sentence denotes 3.
T455 497-578 Sentence denotes Ritonavir SARS-CoV Protease inhibitors Diarrhea, nausea, vomiting, headache [122]
T456 579-581 Sentence denotes 4.
T457 582-701 Sentence denotes Methylprednisolone SARS-CoV Anti-inflammatory effect The onset of diabetes, avascular necrosis, osteoporosis. [132,133]
T458 702-704 Sentence denotes 5.
T459 705-812 Sentence denotes Corticosteroids SARS-CoV Inhibits pro-inflammatory effects Aspergillosis and fungal superinfection [49,134]
T460 813-815 Sentence denotes 6.
T461 816-966 Sentence denotes Methylprednisolone (0.5–1 mg/kg) followed by hydrocortisone (100 mg/8 h) and pulse doses of methylprednisolone (0.5 g for 3 d) Lung diseases – – [124]
T462 967-969 Sentence denotes 7.
T463 970-1068 Sentence denotes Convalescent plasma SARS-CoV, MERS-CoV, SARS-CoV-2 Adaptive or passive immune response – [135,139]
T464 1069-1071 Sentence denotes 8.
T465 1072-1237 Sentence denotes Lopinavir/ritonavir MERS-CoV, SARS-CoV-2 Not effective against MERS, anti-viral therapy for pneumonia caused by SARS-CoV-2 Diarrhea, nausea, vomiting, headache [140]
T466 1238-1240 Sentence denotes 9.
T467 1241-1351 Sentence denotes Pegylated interferon-α Hepatitis-C, MERS-CoV Inhibits DNA synthesis Diarrhea, nausea, vomiting, headache [140]
T468 1352-1355 Sentence denotes 10.
T469 1356-1529 Sentence denotes Lopinavir/ritonavir and IFN-β MERS-CoV Improves pulmonary, reduce viral load, and necrosis in lungs and extrapulmonary tissues Diarrhea, nausea, vomiting, headache [143,144]
T470 1530-1533 Sentence denotes 11.
T471 1534-1743 Sentence denotes Hydroxychloroquine SARS-CoV-2, Malaria Blocks maturation of endosome, maturation and its function by inhibiting the release of virions in the infected cell Diarrhea, nausea, vomiting, headache, dizziness [112]