LitCovid-sentences  

PMC:7243768 / 5591-7377 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T37 0-44 Sentence denotes 2 Mechanism of the pathogenesis of COVID-19
T38 45-186 Sentence denotes The ACE-2 enzyme is found bound to the cell membranes of the cells in the regions of the heart, lungs, kidney, intestines, and arteries [12].
T39 187-289 Sentence denotes This enzyme's function is to degrade the angiotensin II peptide, which acts as a vasoconstrictor [13].
T40 290-361 Sentence denotes Therefore, the ACE2 enzyme is considered to be a potential vasodilator.
T41 362-548 Sentence denotes The SARS-CoV-2 virus binds with the ACE-2 receptor, which mediates the virus's entry into the host cells [14] via the plasma membrane or endocytosis through the release of proteases [2].
T42 549-676 Sentence denotes The activated immune cells secrete chemokines and inflammatory cytokines into the endothelial cells of pulmonary arteries [15].
T43 677-777 Sentence denotes The angiotensin-converting enzyme (ACE) is required to convert angiotensin I to angiotensin II [16].
T44 778-942 Sentence denotes The angiotensin II produced results in vasoconstriction upon the activation of angiotensin II receptors due to which there is an increase in blood pressure [17,18].
T45 943-1031 Sentence denotes Therefore, ACEi and ARBs are used as anti-hypertensive treatment options [18] (Fig. 1 ).
T46 1032-1317 Sentence denotes Fig. 1 The abnormal activation of the Renin-Angiotensin-Aldosterone system (RAAS) pathway via the ACE-AngII-AT1R axis results in vasoconstriction (hypertension) which is treated by the usage of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs).
T47 1318-1593 Sentence denotes Since ACE2 is also the binding receptor for SARS-CoV-2 and enhances the viral entry, replication decreases the level of the ACE2, leading to reduced anti-atrophy and anti-fibrosis anti-inflammation, anti-oxidant, and vasodilation further leads to decreased tissue protection.
T48 1594-1786 Sentence denotes On the other hand, there is a pro-atrophy, pro-fibrosis, pro-inflammation, vasoconstriction, pro-oxidant, and acute lung injury via angiotensin II type 1 receptor which leads to tissue injury.