LitCovid-sentences  

PMC:7243768 / 20377-27312 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T138 0-69 Sentence denotes 5 Middle East Respiratory Syndrome associated coronavirus (MERS-CoV)
T139 70-227 Sentence denotes In Saudi Arabia, in June 2012, a new virus outbreak took place, which caused fever, dry cough, and shortness of breath resulting in respiratory illness [59].
T140 228-318 Sentence denotes The disease spreads from person to person through direct contact with the infected person.
T141 319-466 Sentence denotes It is believed that the MERS-CoV had originated from bats, and dromedary camels are intermediate hosts for transmitting the disease to humans [60].
T142 467-581 Sentence denotes The MERS-CoV belongs to the β group of coronaviruses, and it is a distinct virus from SARS and common flu viruses.
T143 582-728 Sentence denotes The incubation period of this virus is 2–13 days, and it enters the human cells through serine peptidase, dipeptidyl peptidase4 receptors [28,61].
T144 729-857 Sentence denotes The genome of MERS-CoV consists of a single positive-stranded RNA comprising 30,119 nucleotides and 11 open reading frames [62].
T145 858-1112 Sentence denotes The clinical risk factors determining the mortality rate among MERS-CoV infected patients were age, sex, and comorbidities such as cardiovascular diseases, chronic renal diseases, hypertension, diabetes mellitus, cancer, and respiratory diseases [63,64].
T146 1114-1168 Sentence denotes 5.1 MERS-CoV infection along with other comorbidities
T147 1169-1388 Sentence denotes Metabolic disorder related conditions, for example, hypertension, diabetes, obesity, and cardiovascular diseases, together with their inclining conditions, can be connected etiologically to the pathogenesis of MERS-CoV.
T148 1389-1539 Sentence denotes These conditions act to decline the innate immune system of the host, thereby the inability of the host to fight against the pathogenesis of MERS-CoV.
T149 1540-1733 Sentence denotes A study conducted on 637 MERS-CoV patients revealed that 15% of them have diabetes, 16% of them are obese, 50% of them had hypertension, and 30% are predisposed to cardiovascular diseases [65].
T150 1734-2017 Sentence denotes A 57-year-old diabetic and the hypertensive patient exhibited myocardial ischemia besides edema in the pulmonary tract, elevated troponin levels which returned to normal after 48 h, a chronic severe 3-vessel disease with no acute vessel closure characterized by coronary angiography.
T151 2018-2110 Sentence denotes Later, he didn't respond and became hypotensive with facial paralysis on the left side [66].
T152 2112-2138 Sentence denotes 5.2 MERS-CoV-liver injury
T153 2139-2286 Sentence denotes The patients infected by MERS-CoV were also presented with alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels above normal.
T154 2287-2437 Sentence denotes Besides the elevated liver enzymes, the albumin levels were decreased, which serves as an indicator of the severity of the disease [[67], [68], [69]].
T155 2438-2530 Sentence denotes The MERS-CoV enters the host cell through the DPP-4 receptor and spreads the infection [70].
T156 2531-2625 Sentence denotes The liver is the main organ that expresses high levels of Dipeptidyl peptidase 4 (DPP-4) [71].
T157 2626-2992 Sentence denotes This was experimentally proved by infecting the transgenic mice expressing hDPP4 with MERS-CoV which indicated that the liver injury had taken place on the 5th day of the infection as evidenced by the pathological manifestations such as disintegrated death of hepatocytes in the hepatic sinus, penetration of large amounts of activated macrophages and Kupffer cells.
T158 2993-3147 Sentence denotes The changes related to fat metabolism were observed on the 9th day of infection, and the liver cell necrosis was quite less [72] (represented in Table 1).
T159 3148-3361 Sentence denotes The histopathological findings of the hepatic tissue during MERS-CoV infection include infiltration of lobular lymphocytes, mild cellular hydropic degeneration in hepatic parenchyma, and mild portal tract [73,74].
T160 3362-3512 Sentence denotes During the acute phase of infection, the levels of pro-inflammatory cytokines such as TNF-α, IFN-γ, IL-17, and IL-15 were significantly elevated [75].
T161 3513-3694 Sentence denotes But the question of whether liver injury initiated is due to the viral-mediated pathogenesis or due to the drugs that have been used during the viral infection remains elusive [37].
T162 3696-3721 Sentence denotes 5.3 MERS-CoV-lung injury
T163 3722-4082 Sentence denotes The MERS-CoV viral infection mainly affects the lungs resulting in respiratory illness, which was confirmed by the clinical manifestations present in the affected patients which include acute respiratory distress syndrome, septic shock, the mild upper respiratory illness may result in swiftly growing pneumonitis, respiratory failure (represented in Table 1).
T164 4083-4203 Sentence denotes All these events may lead to multi-organ failure, eventually producing lethal effects [60,[76], [77], [78], [79], [80]].
T165 4205-4227 Sentence denotes 5.4 MERS-CoV-CNS risk
T166 4228-4381 Sentence denotes A report presented 3 cases that were infected by MERS-CoV and exhibited abnormal neurological findings along with other predisposed co-morbid conditions.
T167 4382-4558 Sentence denotes A 74 years old patient with co-morbid medical conditions, including dyslipidemia, diabetes, and hypertension, exhibited fever, vomiting, confusion, and ataxia three days later.
T168 4559-4652 Sentence denotes Computerized tomography exhibited no acute changes whereas presented chronic lacunar strokes.
T169 4653-4723 Sentence denotes The chest radiograph revealed infiltration in the mid-right lung zone.
T170 4724-4779 Sentence denotes Decreased motor activity on the left side was observed.
T171 4780-4880 Sentence denotes He was tested positive for MERS-CoV exhibiting respiratory illness, and then he was admitted to ICU.
T172 4881-5045 Sentence denotes On day 24, after hospitalization, his medical condition improved confirmed by tracheostomy, which confirmed an improvement in the respiratory status of the patient.
T173 5046-5133 Sentence denotes The CSF examination revealed lymphopenia and was tested negative for MERS-CoV-2 RT-PCR.
T174 5134-5259 Sentence denotes In 57 years old patient infected with MERS-CoV exhibited neurological findings apart from other cardiovascular abnormalities.
T175 5260-5520 Sentence denotes The neurological findings include bilateral basal ganglia, deep white matter, a large area of hypodensity in the proximal half of the corpus callosum up to the mid part of his body, and interval multiple patchy hypodensities bilaterally in the periventricular.
T176 5521-5835 Sentence denotes MRI examination revealed occipital lobes with a restriction on the diffusion-weighted images (DWI) consistent with acute infarction, and bilaterally in the deep watershed and the parasagittal region scattered foci in the cortical and subcortical regions of the temporal and parietal lobes (represented in Table 1).
T177 5836-5947 Sentence denotes The patient experienced multiple cardiac arrests, severe shock, and acute kidney injury and eventually expired.
T178 5948-6178 Sentence denotes Forty-five-year-old patients with acute kidney injury, diabetes, and hypertension were tested positive for MERS-CoV, and CT scan findings revealed no acute abnormalities but exhibited similar findings consistent with encephalitis.
T179 6179-6263 Sentence denotes The patient exhibited lymphocytopenia and was tested negative after a few days [66].
T180 6265-6294 Sentence denotes 5.5 MERS-CoV-immunopathology
T181 6295-6461 Sentence denotes Like the SARS-CoV, MERS also has an infection in the airway epithelial cells, which enhances the level of pro-inflammatory cytokines and IFN in a delayed manner [81].
T182 6462-6728 Sentence denotes Even in the cells of THP-1, macrophage-derived from the human peripheral blood, dendritic cells showed an elevated level of the chemokines such as CCL3, CCL2, IL-2, IL-8, and CCL-5 and pro-inflammatory cytokines in a delayed manner during MERS-CoV infection [82,83].
T183 6729-6935 Sentence denotes The high level of the pro-inflammatory cytokine and chemokine associated with the enhanced level of the monocyte, neutrophil numbers in both the lung and peripheral blood, which leads to immune damage [84].