PMC:7239011 / 56-3504 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2 0-107 Sentence denotes We read with interest the report of Guillain-Barré syndrome secondary to SARS-Cov-19 infection (Coen et al.
T3 108-114 Sentence denotes 2020).
T4 115-294 Sentence denotes Recently, there have been multiple reports of Guillain-Barré syndrome (GBS) associated with the COVID-19 infection (Sedaghat and Karimi, 2020, Toscano et al.,, Zhao et al., 2020).
T5 295-375 Sentence denotes Most COVID-19-related GBS presented with acute onset of areflexic quadriparesis.
T6 376-467 Sentence denotes However, there are some important differences to highlight (table 1 ). (Garg et al., 2018).
T7 468-521 Sentence denotes Most patients with COVID-19-related GBS were elderly.
T8 522-602 Sentence denotes Preceding symptoms like ageusia and hyposmia were unique for COVID-19 infection.
T9 603-736 Sentence denotes Patients with COVID-19-related GBS had a severe disease with respiratory failure due to lobar pneumonia and interstitial pneumonitis.
T10 737-815 Sentence denotes They showed ground-glass appearance of lungs on chest computerized tomography.
T11 816-895 Sentence denotes Increased severity of disease is also evident from the electrophysiology study.
T12 896-1115 Sentence denotes Where demyelinating neuropathy is more common with typical GBS and GBS related to dengue and Zika virus, majority of COVID-19-related GBS patients had axonal motor (AMAN) and axonal motor-sensory polyneuropathy (AMSAN).
T13 1116-1217 Sentence denotes A few of these patients showed enhancement of caudal nerve roots on Gadolinium-enhanced MRI of spine.
T14 1218-1357 Sentence denotes Most COVID-19 patients received hydroxychloroquine, azithromycin, lopinavir and ritonavir in addition to intravenous immunoglobulin (IVIG).
T15 1358-1475 Sentence denotes However, more than half of patients showed poor outcome in the form of long ICU stay, residual paresis and dysphagia.
T16 1476-1578 Sentence denotes Table 1 Differences in the presentation of Typical GBS, Dengue, Zika virus and COVID SARS related GBS.
T17 1579-1663 Sentence denotes Feature Typical GBS Dengue-related GBS Zika virus-related GBS COVID SARS related GBS
T18 1664-3307 Sentence denotes Geographical distributionAgeSexPreceding illnessMean time to GBSInitial symptomsDysphagiaSignsFacial diplegiaDysautonomiaAtaxiaRespiratory failureOther cranial nerves involvedLeukopeniaThrombocytopeniaNerve conductionCT chestMRI Brain/spineTreatmentOutcome GlobalAll age groupsMales 1.5 times more affectedRespiratory or gastrointestinal< 6 weeksParesthesia, pain followed by weakness of limbsLess commonAreflexic quadreparesisCommonCommonLess common25%Ocular nervesUncommonUncommonAIDP--IVIG, PlasmapherisisGood, persistent disability in 20%-30% Latin America, IndiaAll age groupsMales:Females EqualFever, rash, myalgia, headache1–30 daysAscending weakness, paresthesia, facial weaknessLess commonAreflexic quadri/paraparesisCommonLess commonLess commonLess commonGlossopharyngeal nerveCommonCommonAIDP, AMSAN--IVIG, PlasmapheresisGood Latin America, Europe, East Asia, North AmericalMiddle age to elderlyMore malesFever, headache, rash, arthralgia, diarrhea, conjunctivitis0–10 daysLimb pains, paresthesia, lower limb weakness, facial weaknessMore commonAreflexic quadri/paraparesisCommon (>50%)Common (up to 30%)Common (up to 70%)Less common3rd cranial nerve--AIDP > AMAN, AMSAN--IVIG, PlasmapheresisGood, half may require ICU care China, Iran, Europe, USAUsually elderlyMore malesFever, cough, dyspnea, ageusia, hyposmia5–14 daysParesthesia, lower limb weakness, facial weaknessLess commonAreflexic quadri/paraparesisCommonLess commonLess commonCommon-Common-AMSAN, AMAN, AIDPPneumonia, interstitial pneumonitisEnhancement of caudal nerve rootsIVIG, Lopinavir, ritonavir, HCQ, Azithromycin,Poor, residual weakness, dysphagia, long ICU stay
T19 3308-3448 Sentence denotes AIDP – Acute inflammatory demyelinating polyneuropathy, AMAN – Acute motor axonal neuropathy, AMSAN – Acute motor sensory axonal neuropathy.