> top > projects > LitCovid-sentences > docs > PMC:7239011 > annotations
LitCovid-sentences  

PMC:7239011 JSONTXT 18 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-54 Sentence denotes Is COVID-19-related Guillain-Barré syndrome different?
T2 56-163 Sentence denotes We read with interest the report of Guillain-Barré syndrome secondary to SARS-Cov-19 infection (Coen et al.
T3 164-170 Sentence denotes 2020).
T4 171-350 Sentence denotes Recently, there have been multiple reports of Guillain-Barré syndrome (GBS) associated with the COVID-19 infection (Sedaghat and Karimi, 2020, Toscano et al.,, Zhao et al., 2020).
T5 351-431 Sentence denotes Most COVID-19-related GBS presented with acute onset of areflexic quadriparesis.
T6 432-523 Sentence denotes However, there are some important differences to highlight (table 1 ). (Garg et al., 2018).
T7 524-577 Sentence denotes Most patients with COVID-19-related GBS were elderly.
T8 578-658 Sentence denotes Preceding symptoms like ageusia and hyposmia were unique for COVID-19 infection.
T9 659-792 Sentence denotes Patients with COVID-19-related GBS had a severe disease with respiratory failure due to lobar pneumonia and interstitial pneumonitis.
T10 793-871 Sentence denotes They showed ground-glass appearance of lungs on chest computerized tomography.
T11 872-951 Sentence denotes Increased severity of disease is also evident from the electrophysiology study.
T12 952-1171 Sentence denotes Where demyelinating neuropathy is more common with typical GBS and GBS related to dengue and Zika virus, majority of COVID-19-related GBS patients had axonal motor (AMAN) and axonal motor-sensory polyneuropathy (AMSAN).
T13 1172-1273 Sentence denotes A few of these patients showed enhancement of caudal nerve roots on Gadolinium-enhanced MRI of spine.
T14 1274-1413 Sentence denotes Most COVID-19 patients received hydroxychloroquine, azithromycin, lopinavir and ritonavir in addition to intravenous immunoglobulin (IVIG).
T15 1414-1531 Sentence denotes However, more than half of patients showed poor outcome in the form of long ICU stay, residual paresis and dysphagia.
T16 1532-1634 Sentence denotes Table 1 Differences in the presentation of Typical GBS, Dengue, Zika virus and COVID SARS related GBS.
T17 1635-1719 Sentence denotes Feature Typical GBS Dengue-related GBS Zika virus-related GBS COVID SARS related GBS
T18 1720-3363 Sentence denotes Geographical distributionAgeSexPreceding illnessMean time to GBSInitial symptomsDysphagiaSignsFacial diplegiaDysautonomiaAtaxiaRespiratory failureOther cranial nerves involvedLeukopeniaThrombocytopeniaNerve conductionCT chestMRI Brain/spineTreatmentOutcome GlobalAll age groupsMales 1.5 times more affectedRespiratory or gastrointestinal< 6 weeksParesthesia, pain followed by weakness of limbsLess commonAreflexic quadreparesisCommonCommonLess common25%Ocular nervesUncommonUncommonAIDP--IVIG, PlasmapherisisGood, persistent disability in 20%-30% Latin America, IndiaAll age groupsMales:Females EqualFever, rash, myalgia, headache1–30 daysAscending weakness, paresthesia, facial weaknessLess commonAreflexic quadri/paraparesisCommonLess commonLess commonLess commonGlossopharyngeal nerveCommonCommonAIDP, AMSAN--IVIG, PlasmapheresisGood Latin America, Europe, East Asia, North AmericalMiddle age to elderlyMore malesFever, headache, rash, arthralgia, diarrhea, conjunctivitis0–10 daysLimb pains, paresthesia, lower limb weakness, facial weaknessMore commonAreflexic quadri/paraparesisCommon (>50%)Common (up to 30%)Common (up to 70%)Less common3rd cranial nerve--AIDP > AMAN, AMSAN--IVIG, PlasmapheresisGood, half may require ICU care China, Iran, Europe, USAUsually elderlyMore malesFever, cough, dyspnea, ageusia, hyposmia5–14 daysParesthesia, lower limb weakness, facial weaknessLess commonAreflexic quadri/paraparesisCommonLess commonLess commonCommon-Common-AMSAN, AMAN, AIDPPneumonia, interstitial pneumonitisEnhancement of caudal nerve rootsIVIG, Lopinavir, ritonavir, HCQ, Azithromycin,Poor, residual weakness, dysphagia, long ICU stay
T19 3364-3504 Sentence denotes AIDP – Acute inflammatory demyelinating polyneuropathy, AMAN – Acute motor axonal neuropathy, AMSAN – Acute motor sensory axonal neuropathy.
T20 3505-3558 Sentence denotes Is COVID-19-related GBS has a different pathogenesis?
T21 3559-3776 Sentence denotes The polyneuropathy in GBS is believed to be due to cross-immunity against epitopes of peripheral nerve components that it shares with the epitopes on the cell surface of bacteria that produces an antecedent infection.
T22 3777-3877 Sentence denotes This mechanism of “molecular mimicry” is best understood with the Campylobacter jejuni -related GBS.
T23 3878-3945 Sentence denotes C. jejuni expresses various gangliosides antigen on its outer core.
T24 3946-4109 Sentence denotes Antecedent infection with C. jejuni results in antibody formation against specific gangliosides present on axonal membrane (GM1, GD1a, GalNac-GD1a, GD1b and GQ1b).
T25 4110-4254 Sentence denotes Presence of these anti-ganglioside antibodies is strongly associated with AMAN, AMSAN and Miller-Fischer variants of GBS (Ogawara et al., 2000).
T26 4255-4360 Sentence denotes The cross-immunity between viral antigens and peripheral nerve glycolipids have not been well-documented.
T27 4361-4466 Sentence denotes Positive GD1a antibody was reported in a few patients with dengue virus-related GBS (Simon et al., 2016).
T28 4467-4587 Sentence denotes Anti-ganglioside antibody was not found in patients with COVID-19 and Zika virus-related GBS (Cao-Lormeau et al., 2016).
T29 4588-4803 Sentence denotes This has led to speculation that the neuropathy in viral infections-related GBS could be due to other autoantibodies that are not detected as yet or the viruses produced nerve damage due to other neurotoxic effects.
T30 4804-4924 Sentence denotes However, there is paucity of evidence of direct infection of peripheral nerves by viruses from the pathological studies.
T31 4925-5044 Sentence denotes Good response to immunotherapy in viral infection-related GBS is also against the direct neurotoxic effects of viruses.
T32 5045-5214 Sentence denotes COVID-19 patients with AIDP responded better as compared to those with axonal variants of GBS; a difference also seen in patients with dengue and Zika virus-related GBS.
T33 5215-5318 Sentence denotes Recently, a good clinical response in pneumonia has been seen in COVID-19 patients with plasma therapy.
T34 5319-5403 Sentence denotes Does plasma therapy produce good recovery in COVID-19-related GBS is yet to be seen.
T35 5405-5438 Sentence denotes Declaration of Competing Interest
T36 5439-5609 Sentence denotes The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
T37 5611-5641 Sentence denotes Appendix A Supplementary data
T38 5642-5719 Sentence denotes The following are the Supplementary data to this article:Supplementary data 1
T39 5721-5736 Sentence denotes Acknowledgement
T40 5737-5742 Sentence denotes None.
T41 5743-5750 Sentence denotes Funding
T42 5751-5788 Sentence denotes The work did not receive any funding.
T43 5789-5901 Sentence denotes Appendix A Supplementary data to this article can be found online at https://doi.org/10.1016/j.bbi.2020.05.051.