| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T299 |
0-204 |
Sentence |
denotes |
A separate strategy has used combinations of amino acid residues from the FcγR‐binding regions of IgG2 and IgG4, which have restricted FcγR specificity, together with other binding‐inactivating mutations. |
| T300 |
205-383 |
Sentence |
denotes |
The lower hinge amino acids of the IgG1 mAbs durvalumab (anti‐PD‐L1) and anifrolumab (anti‐interferon‐α receptor; Table 4) were modified to mimic the lower hinge of IgG4 (L234F). |
| T301 |
384-601 |
Sentence |
denotes |
They additionally incorporated L235E in the lower hinge and P331S in the F/G loop of the CH2 domain to ablate FcγR binding by disrupting two major FcγR contact sites7 and also coincidently decreasing C1q activation.16 |
