LitCovid-sentences  

PMC:7219429 / 629-2409 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T10 0-135 Sentence denotes The emergence of SARS-coronavirus-2 (SARS-CoV-2) has led to a global pandemic disease referred to as coronavirus disease 19 (COVID-19).
T11 136-283 Sentence denotes Hydroxychloroquine (CLQ-OH)/azithromycin (ATM) combination therapy is currently being tested for the treatment of COVID-19, with promising results.
T12 284-370 Sentence denotes However, the molecular mechanism of action of this combination is not yet established.
T13 371-546 Sentence denotes Using molecular dynamics (MD) simulations, this study shows that the drugs act in synergy to prevent any close contact between the virus and the plasma membrane of host cells.
T14 547-715 Sentence denotes Unexpected molecular similarity is shown between ATM and the sugar moiety of GM1, a lipid raft ganglioside acting as a host attachment cofactor for respiratory viruses.
T15 716-815 Sentence denotes Due to this mimicry, ATM interacts with the ganglioside-binding domain of SARS-CoV-2 spike protein.
T16 816-952 Sentence denotes This binding site shared by ATM and GM1 displays a conserved amino acid triad Q-134/F-135/N-137 located at the tip of the spike protein.
T17 953-1124 Sentence denotes CLQ-OH molecules are shown to saturate virus attachment sites on gangliosides in the vicinity of the primary coronavirus receptor, angiotensin-converting enzyme-2 (ACE-2).
T18 1125-1262 Sentence denotes Taken together, these data show that ATM is directed against the virus, whereas CLQ-OH is directed against cellular attachment cofactors.
T19 1263-1372 Sentence denotes We conclude that both drugs act as competitive inhibitors of SARS-CoV-2 attachment to the host-cell membrane.
T20 1373-1523 Sentence denotes This is consistent with a synergistic antiviral mechanism at the plasma membrane level, where therapeutic intervention is likely to be most efficient.
T21 1524-1644 Sentence denotes This molecular mechanism may explain the beneficial effects of CLQ-OH/ATM combination therapy in patients with COVID-19.
T22 1645-1780 Sentence denotes Incidentally, the data also indicate that the conserved Q-134/F-135/N-137 triad could be considered as a target for vaccine strategies.