PMC:7219429 / 28977-29595 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T211 0-181 Sentence denotes The molecular mimicry between ATM and the saccharide part of GM1 gives new perspectives on the therapeutic effect of this macrolide antibiotic and this warrants further exploration.
T212 182-374 Sentence denotes Moreover, the fact that ganglioside GM1 is a molecular target for CLQ-OH might explain the indication of this drug in rheumatological disorders, such as lupus and rheumatoid arthritis [35,36].
T213 375-467 Sentence denotes Indeed, GM1 overexpression and anti-GM1 antibodies are a hallmark of these diseases [37,38].
T214 468-618 Sentence denotes Thus, our data incidentally indicate that the therapeutic effect of CLQ-OH in these cases could also be related to its ganglioside-binding properties.