| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T205 |
0-100 |
Sentence |
denotes |
The posology of the combination therapy for COVID-19 is 600 mg CLQ-OH and 250 mg ATM per day [3,34]. |
| T206 |
101-168 |
Sentence |
denotes |
This ratio corresponds to a molar ratio of five CLQ-OH for one ATM. |
| T207 |
169-276 |
Sentence |
denotes |
In silico calculations indicate a binding ratio of four CLQ-OH for one ATM, which is close to the posology. |
| T208 |
277-486 |
Sentence |
denotes |
Furthermore, as ATM shares structural similarity with the saccharide part of GM1, one should ask whether ATM could bind to CLQ-OH and by this way reduce the potential effectiveness of this combination therapy. |
| T209 |
487-646 |
Sentence |
denotes |
However, as ATM and CLQ-OH have been reported to synergistically decrease SARS-CoV-2 load in infected patients [3], drug cross-neutralization is very unlikely. |
| T210 |
647-777 |
Sentence |
denotes |
There was a consistent lack of evidence of any stable ATM-CLQ-OH complexes using the molecular modelling approaches in this study. |
