LitCovid-sentences  

PMC:7219429 / 2411-5577 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
T23 0-15 Sentence denotes 1 Introduction
T24 16-176 Sentence denotes The emergence of the novel pathogenic SARS-coronavirus 2 (SARS-CoV-2) has led to a global pandemic disease referred to as coronavirus disease 19 (COVID-19) [1].
T25 177-257 Sentence denotes In such a health emergency, it is critical to find a cure and stop the pandemic.
T26 258-482 Sentence denotes Among the potential solutions currently under investigation, a combination bitherapy consisting of the antimalarial drug, hydroxychloroquine (CLQ-OH) with the antibiotic, azithromycin (ATM) has received particular attention.
T27 483-674 Sentence denotes Following initial reports from China indicating a potential effect of chloroquine (CLQ) [2], a preliminary clinical trial was implemented in France on a small cohort of COVID-19 patients [3].
T28 675-846 Sentence denotes A significant viral load reduction was observed in the 20 patients treated with CLQ-OH [3], a CLQ derivative with increased solubility in water and decreased toxicity [4].
T29 847-968 Sentence denotes With the aim of preventing bacterial super-infection, six additional patients in this trial also received ATM for 5 days.
T30 969-1033 Sentence denotes All these patients had undetectable viral load after 6 days [3].
T31 1034-1225 Sentence denotes Thus, although these promising data need clinical confirmation with more patients, CLQ-OH/ATM combination therapy already appears superior to CLQ alone as a first-line treatment for COVID-19.
T32 1226-1362 Sentence denotes Both CLQ-OH and ATM are repositioned drugs and their antiviral mechanism of action, particularly in combination, remains mostly unclear.
T33 1363-1437 Sentence denotes In vitro studies have shown that CLQ-OH inhibits SARS-CoV-2 [4], [5], [6].
T34 1438-1571 Sentence denotes Far less is known about the antiviral effects of ATM, which has been suggested to interfere with influenza virus internalization [7].
T35 1572-1689 Sentence denotes Interestingly, CLQ is also considered as an inhibitor of endocytic pathways through an elevation of endosomal pH [8].
T36 1690-1831 Sentence denotes However, several reports indicate that CLQ could also prevent virus attachment through a direct effect on host-cell surface molecules [9,10].
T37 1832-2082 Sentence denotes The first step of the replication cycle in human coronaviruses is the attachment of the virus to the host plasma membrane, which is mediated by a membrane protein receptor, i.e., angiotensin-converting enzyme-2 (ACE-2) in the case of SARS-CoV-2 [11].
T38 2083-2273 Sentence denotes Moreover, coronaviruses are also dependent upon sialylated membrane components, such as gangliosides, which act as attachment cofactors within lipid raft membrane platforms [12], [13], [14].
T39 2274-2497 Sentence denotes As ACE-2 is localized in lipid rafts [15], SARS-CoV-2 infection requires specific targeting to these plasma membrane microdomains, where multivalent interactions between the spike protein and raft components can take place.
T40 2498-2657 Sentence denotes In line with this notion, lipid raft disruption through cholesterol depletion resulted in a significant reduction of human coronavirus SARS-CoV infection [15].
T41 2658-2943 Sentence denotes The recent identification of a potential ganglioside-binding domain in the N-terminal domain (NTD) of the SARS-CoV-2 spike protein, and its potential role in membrane recognition [10], prompted this study of the molecular relationship between this domain, gangliosides, ATM and CLQ-OH.
T42 2944-3166 Sentence denotes This study involved a molecular modelling strategy that has been successfully applied to unravel the molecular mechanisms of protein binding to raft lipid components, including gangliosides [16,17] and cholesterol [18,19].