LitCovid-sentences  

PMC:7219429 / 22691-25140 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T168 0-62 Sentence denotes This study also looked at CLQ-OH and its interaction with GM1.
T169 63-162 Sentence denotes We recently published a model describing a complex formed by one GM1 and two CLQ-OH molecules [10].
T170 163-302 Sentence denotes For comparison, the same molecular modelling approaches as for ATM (in the presence of surrounding raft lipids) were applied to this model.
T171 303-431 Sentence denotes A stable complex formed by a ganglioside dimer, each monomer being associated with two CLQ-OH molecules, was obtained (Fig. 8d).
T172 432-600 Sentence denotes The stability of this complex is reinforced by a rearrangement of CLQ-OH molecules that interact with each other as well as interacting with the saccharide part of GM1.
T173 601-762 Sentence denotes Consequently, the surface of the ganglioside is almost completely masked, so that the ganglioside dimer can no longer be recognized by the viral spike (Fig. 8c).
T174 763-944 Sentence denotes In the presence of both ATM and CLQ-OH, virus-ganglioside interactions are efficiently blocked, preventing any close contact between the virus and the plasma membrane of host cells.
T175 945-1025 Sentence denotes The molecular details of this synergistic antiviral effect are worth mentioning.
T176 1026-1043 Sentence denotes As shown in Figs.
T177 1044-1182 Sentence denotes 5 and 8e and Table S1, the QFN triad of the virus spike protein is predicted to interact with the central region of the ganglioside dimer.
T178 1183-1302 Sentence denotes If the dimer is compared metaphorically to a butterfly, this region corresponds to the insect's head between the wings.
T179 1303-1429 Sentence denotes For its part, CLQ-OH binds to the wings (Fig. 8d), whereas ATM neutralizes the QFN triad of the virus spike protein (Fig. 8f).
T180 1430-1581 Sentence denotes Indeed, all attempts to obtain a stable raft-spike protein complex aborted when GM1 was covered by CLMQ-OH and when ATM was bound to the spike protein.
T181 1582-1838 Sentence denotes In the case of ATM, these data confirm that the QFN triad is critical for GM1 recognition and that although other residues are involved (Fig. 5 and Table S1), the whole binding process is fully controlled by the primary interaction driven by the QFN triad.
T182 1839-1984 Sentence denotes In agreement with this notion, mutating the QFN triad with alanine residues resulted in an aborted ATM binding process at the post-docking steps.
T183 1985-2349 Sentence denotes Taken together, these molecular modelling studies indicate that CLQ-OH and ATM, when bound to their respective targets, totally mask the complementary surfaces provided by the lipid raft and the virus spike (Fig. 8c): CLQ-OH binds to GM1 and covers the wing, ATM binds to the virus spike and prevents any interaction with the central area of the ganglioside dimer.
T184 2350-2449 Sentence denotes Hence, both drugs act as competitive inhibitors of SARS-CoV-2 attachment to the host-cell membrane.