PMC:7219429 / 21534-22690 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T162 302-445 Sentence denotes Note that both ATM and gangliosides share the same binding region. (c) ATM prevents ganglioside binding to the SARS-CoV-2 spike protein trimer.
T163 446-613 Sentence denotes CLQ-OH, once bound to gangliosides (blue and orange surfaces), also prevents any interaction with the viral spike. (d) 4 CLQ-OH molecules bound to a ganglioside dimer.
T164 614-806 Sentence denotes Each GM1 molecule is blocked by two CLQ-OH molecules (blue and orange surfaces), which wrap around the saccharide part. (e) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to GM1.
T165 807-957 Sentence denotes Note that the ganglioside interacts with Q-134 and F-135, but not with D-138. (f) Detail of the 134-138 SARS-CoV-2 spike protein stretch bound to ATM.
T166 958-1035 Sentence denotes In this case, the binding site includes D-138 in addition to Q-134 and F-135.
T167 1036-1156 Sentence denotes Note that N-137, which interacts with both ATM and GM1, is not visible in these representations as it is located behind.