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PMC:7214331 JSONTXT 18 Projects

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Id Subject Object Predicate Lexical cue
T1 0-66 Sentence denotes Problems related with anticoagulant usage during COVID-19 outbreak
T2 68-250 Sentence denotes The current COVID-19 pandemic has led to many countries asking or requiring their citizens to stay home to avoid potentially contacting the disease or exposing others to the disease.
T3 251-353 Sentence denotes Older patients with comorbidities are at particular risk of developing severe infection with COVID-19.
T4 354-429 Sentence denotes Many people on anticoagulation are older and have significant comorbities.1
T5 430-557 Sentence denotes In many countries, including Turkey, governments have imposed restrictions on travel from home to limit the spread of COVID-19.
T6 558-772 Sentence denotes Although so-called “sheltering in place” is proving to be an effective way to decrease community transmission, patients receiving vitamin K antagonist (VKA) treatment, like warfarin, may be harmed by such policies.
T7 773-1141 Sentence denotes Routine reporting of patients to outpatient clinics of hospitals or laboratories for checking their international normalized ratio (INR) places them at risk for community-acquired infection from COVID-19, whereas not traveling for INR checks places them at risk for a complication of over- or under-anticoagulation as INR levels can be labile in many patients on VKAs.
T8 1142-1556 Sentence denotes According to the current national and international guidelines, although therapy with novel oral anticoagulants (NOACs) is suggested over VKAs, due to reimbursement problems, many people with deep vein thrombosis of the leg or pulmonary embolism are still receiving VKA therapy.2 , 3 VKAs are also used after venous stenting procedures in patients with chronic venous occlusion syndromes to avoid stent thrombosis.
T9 1557-1682 Sentence denotes Although there are no definite recommendations about anticoagulation after venous stenting, many patients are receiving VKAs.
T10 1683-1810 Sentence denotes Patients with mechanical heart valve replacement also need to use VKAs for long-term anticoagulant therapy to avoid thrombosis.
T11 1811-1942 Sentence denotes Current guidelines for the management of valvular heart diseases favor VKAs for long-term therapy after valve replacement surgery.4
T12 1943-2101 Sentence denotes Therefore, many patients need to travel to hospitals or laboratories to screen their INR levels, and it makes them more susceptible to the COVID-19 infection.
T13 2102-2461 Sentence denotes If possible during the current COVID-19 pandemic, patients requiring anticoagulant therapy for deep vein thrombosis, venous stent therapy, and nonvalvular atrial fibrillation should be converted to NOACs for decreasing their need to travel from home to avoid COVID-19 transmission without increasing their risk for anticoagulant therapy-related complications.
T14 2462-2735 Sentence denotes For patients with mechanical heart valves or who are unable to be treated with an NOAC therapy, INR in-home testing machines can be a convenient alternative method and allow patients to check their INR levels without a need for frequent visits to hospitals or laboratories.
T15 2736-2814 Sentence denotes Thus, a decrease in hospital visits leads to minimizing COVID-19 transmission.
T16 2815-2907 Sentence denotes Patients need to consult their doctors for interval of tests and results for adjusting VKAs.
T17 2908-3076 Sentence denotes As a result, considering that COVID-19 is transmitted by inhalation and close contact, the in-home INR test method and consulting the results by phone may be favorable.
T18 3077-3156 Sentence denotes For those who are suitable for NOACs should be converted from a VKA to an NOAC.
T19 3157-3300 Sentence denotes Such measures are important precautions to prevent the spread and inevitable consequences of disease in patients under anticoagulant therapies.